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针对ALK+非小细胞肺癌的向治疗和血栓形成之间的相关性:系统性审查和网络元分析

Yaopu Qi¹, Xiuhuan Wang¹, Tai Guo¹

¹Department of Respiratory Medicine, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.

|September 30, 2024

概括

与化学疗法和其他ALK氨酸激酶抑制剂 (TKIs) 相比,克里佐替尼显著增加了对形淋巴瘤激酶 (ALK) 阳性非小细胞肺癌患者的血栓栓栓塞 (TE) 和静脉TE (VTE) 的风险. 其他ALK-TKIs如布里加替尼和谢里替尼显示TE风险低于crizotinib.

科学领域:

在瘤学瘤学.
药理学药理学是指药理学的学科.
临床试验临床试验

背景情况:

无性淋巴瘤激酶 (ALK) 阳性非小细胞肺癌 (NSCLC) 用ALK氨酸激酶抑制剂 (TKIs) 和化疗治疗.
血栓栓塞栓症 (TE) 是NSCLC治疗中的一个重要问题.

研究的目的:

为了比较ALK阳性NSCLC不同辅助治疗选择中的血栓栓塞 (TE) 发生率.
评估ALK-TKIs和化疗对TE事件的比较安全概况.

主要方法:

系统审查和贝叶斯网络元分析 (NMA) 已发表的随机对照试验 (RCT).
在2023年6月之前搜索了主要数据库 (PubMed,Embase,Cochrane,ClinicalTrials.gov,Web of Science)
使用Cochrane工具评估了偏差风险,并在R.中使用GEMTC进行了NMA.

主要成果:

与crizotinib相比,化疗,布里加替尼和谢里替尼的总TE风险较低.
对静脉TE (VTE) 的类似发现,化学疗法,布里加替尼和谢里替尼的发生率低于crizotinib.
在治疗组之间没有观察到动脉TE风险的显著差异.

结论:

与化疗,alectinib,lorlatinib,brigatinib和ceritinib相比,crizotinib显著增加了TE和VTE的风险.
这表明其他ALK-TKIs和化疗对ALK阳性NSCLC中TE事件更有利的安全概况.

关键词:

化学疗法化疗化疗瘤基因的基因基因.呼吸道瘤呼吸道瘤系统性审查系统性审查血栓塞栓症血栓塞栓症血栓塞栓症

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