对长非编码RNAHOTAIR多态和癌症风险的全面调查:目前的分析包括96,458名参与者
B Madhu Krishna1, Pankaj Garg2, Sravani Ramisetty1
1Department of Medical Oncology, Beckman Research Institute, City of Hope Comprehensive Cancer Center and National Medical Center, Duarte, CA, 91010, USA.
Scientific reports
|September 30, 2024
概括
长非编码RNAHOTAIR中的遗传变异影响癌症易感性. 特定的HOTAIR多态 (rs1899663和rs4759314) 与癌症风险增加有关,特别是在亚洲人群中,这表明潜在的诊断价值.
科学领域:
- 遗传学 是一个遗传学.
- 在瘤学瘤学.
- 分子生物学分子生物学
背景情况:
- 癌症是全球主要的死亡原因.
- 遗传变异或多态性与癌症易感性有关.
- 长非编码RNAHOTAIR (lncRNAHOTAIR) 是癌症研究的一个重点,但其作用仍在争论中.
研究的目的:
- 系统地分析HOTAIR基因多态和癌症风险之间的关联.
- 为了澄清之前关于HOTAIR和癌症的研究中的不一致性.
- 为了研究特定的HOTAIR多态 (rs920778, rs1899663, rs4759314) 和它们与癌症的联系.
主要方法:
- 进行了48项病例控制研究的元分析.
- 包括42,321例癌症病例和54,137例对照病例的数据.
- 收集了来自PubMed,EMBASE和谷歌学者的研究.
主要成果:
- 在HOTAIR rs1899663 G>T和rs4759314 A>G多态和整体癌症风险之间发现了显著的相关性.
- 关联在同卵性和衰退性遗传模型中尤为明显.
- 亚组分析显示,与伊朗人相比,亚洲人群的联系更强.
- 霍泰尔多态可能作为诊断标记,特别是对于妇科癌和乳腺癌 (rs1899663).
结论:
- 长非编码RNAHOTAIR多态性与癌症风险有关.
- 特定的HOTAIR多态表现为某些癌症和人群的诊断标记物具有潜力.
- 这些发现表明,HOTAIR多态体在癌症诊断中的临床相关性.
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