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相关概念视频

The Tumor Microenvironment02:17

The Tumor Microenvironment

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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相关实验视频

Updated: Jun 11, 2025

Visualization, Quantification, and Mapping of Immune Cell Populations in the Tumor Microenvironment
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空间相互作用调节瘤生长和免疫透.

Sadegh Marzban1, Sonal Srivastava2, Sharon Kartika3

  • 1Integrated Mathematical Oncology Department, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA.

NPJ systems biology and applications
|September 30, 2024
PubMed
概括

计算模型揭示了状细胞癌中的原纤维对齐如何有助于瘤免疫逃生. 高水平的原蛋白保护瘤,导致后期疾病阶段免疫细胞覆盖率降低.

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科学领域:

  • 在瘤学瘤学.
  • 计算生物学 计算生物学
  • 免疫学 免疫学 免疫学

背景情况:

  • 在固体瘤中直接观察瘤与免疫相互作用仍然具有技术挑战性.
  • 假设原蛋白模式有助于瘤免疫逃逸,但免疫-原蛋白相互作用的精确机制尚不清楚.
  • 状细胞癌的空间分析显示,在晚期阶段,原纤维对齐度增加.

研究的目的:

  • 用计算建模研究原纤维对齐在瘤免疫相互作用中的作用.
  • 测试有关免疫细胞迁移相对于原纤维方向的假设.
  • 阐明原蛋白影响免疫细胞透和瘤进展的机制.

主要方法:

  • 开发一个计算建模框架来模拟瘤-免疫相互作用.
  • 从临床状细胞癌样本中对原纤维对齐的空间数据的整合.
  • 两种免疫细胞迁移假设之间的歧视:与原纤维平行或垂直.
  • 核心细胞-细胞相互作用函数的定义,捕捉局部和全球空间相互作用.

主要成果:

  • 计算模型总结了免疫-细胞外矩阵相互作用,证明了原蛋白对免疫细胞的保护作用.
  • 疾病阶段和免疫细胞覆盖率之间出现了反向关系,与原对齐相关.
  • 短距离相互作用核在Allee效应下支持瘤细胞生存.
  • 不对称的瘤免疫相互作用核导致免疫反应减弱.

结论:

  • 状细胞癌中的原纤维对齐可以作为免疫逃脱的机制.
  • 计算建模为瘤免疫动态和细胞外矩阵影响提供了关键的机械洞察力.
  • 瘤-免疫相互作用核的空间尺度显著影响瘤生长,透和整体免疫反应.