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Updated: Jun 11, 2025

A Tailored HPLC Purification Protocol That Yields High-purity Amyloid Beta 42 and Amyloid Beta 40 Peptides, Capable of Oligomer Formation
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A Tailored HPLC Purification Protocol That Yields High-purity Amyloid Beta 42 and Amyloid Beta 40 Peptides, Capable of Oligomer Formation

Published on: March 27, 2017

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粉样β (Aβ40) 在通过液-液相分离产生的凝结物中聚合

Owen M Morris1, Zenon Toprakcioglu1, Alexander Röntgen1

  • 1Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, UK.

Scientific reports
|September 30, 2024
PubMed
概括

阿尔茨海默病涉及粉样蛋白-β (Aβ) 的聚合. 这项研究表明,Aβ40可以形成液滴,转化为粉样纤维,为神经退行性疾病机制提供了新的见解.

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相关概念视频

Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
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