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在B组中表面蛋白质的分布从南非分离的链球菌和通过in silico分析识别疫苗点

Vicky Gent¹, Ying-Jie Lu², Sindiswa Lukhele¹

¹South African Medical Research Council: Vaccines and Infectious Diseases Analytics Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.

Scientific reports

|September 30, 2024

概括

婴儿和孕妇需要接种B组链球菌 (GBS) 疫苗. 这项研究确定了9种具有高抗原性的新型GBS蛋白,显示出作为有效疫苗点的潜力.

科学领域:

微生物学微生物学
疫苗学疫苗学疫苗学
生物信息学是一种生物信息学.

背景情况:

乙组链球菌 (GBS) 在新生儿和孕妇中引起严重感染,目前没有疫苗可用.
基因组测序揭示了潜在的GBS疫苗候选人,需要进一步调查它们的特性.

研究的目的:

通过使用in silico反向疫苗学来识别和评估保存和免疫性GBS蛋白质作为潜在的疫苗点.
评估南非分离品中GBS蛋白的流行,保存,抗原性和结构性质.

主要方法:

在 silico反向疫苗学中,用于选89个候选GBS蛋白质,对抗648个侵入性和603个殖民性GBS分离物.
蛋白质的评估基于遗传保护,抗原性,物理化学性质,亚细胞局部化和表位预测.

主要成果:

十个GBS蛋白被发现是高度保守的;九个是计算推断的蛋白质,一个是表面免疫蛋白 (SIP).
与SIP相比,这些保存的蛋白质中的9种显示出较高的抗原性得分 (>0.6498),表明它们具有作为疫苗抗原的强大潜力.

结论:

这项研究确定了9种新的GBS蛋白质,具有作为疫苗抗原标的巨大潜力.
这些发现为开发新型GBS疫苗以对抗脆弱人群感染提供了基础.

关键词:

B组的链球菌.在状的中.孕产妇的疫苗接种方式流行程度流行程度疫苗的研发工作正在进行中.

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