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Updated: Jun 11, 2025

In Vivo Modeling of the Morbid Human Genome using Danio rerio
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谈论疾病;开发一种患者和公众优先考虑的疾病表型模型

Karin Slater1,2,3,4, Paul N Schofield5, James Wright6

  • 1Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK. k.slater@bham.ac.uk.

NPJ digital medicine
|September 30, 2024
PubMed
概括

社交媒体数据揭示了公众对疾病表型的观点,识别了在学术文献中没有发现的新兴关联. 这些公共卫生数据为临床意识和患者护理提供了宝贵的见解.

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Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
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