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Updated: Jun 11, 2025

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Cbx4 SUMOylates BRD4 调节在创伤后关节炎中炎症性细胞因子的表达

Ding Zhou1, Jia-Ming Tian1, Zi Li1

  • 1Department of Orthopedics, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.

Experimental & molecular medicine
|September 30, 2024
PubMed
概括

E3 SUMO 蛋白质结合酶 CBX4 修改了 Bromodomain 4 (BRD4),在创伤后关节炎 (PTOA) 中增加了炎症基因表达. 抑制CBX4缓解PTOA,突出炎症中的CBX4-BRD4轴.

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