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Updated: Jun 11, 2025

Efficient PAM-Less Base Editing for Zebrafish Modeling of Human Genetic Disease with zSpRY-ABE8e
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快速生成长,化学修饰的pegRNAs用于主要编辑

Xinlin Lei1,2, Anhui Huang1,2, Didi Chen1,2

  • 1Departments of Urology and Laboratory Medicine, Frontier Science Center for Immunology and Metabolism, Medical Research Institute, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, China.

Nature biotechnology
|September 30, 2024
PubMed
概括

我们开发了一种快速,负担得起的方法来创建长质编辑指导RNA (pegRNAs) 和工程 pegRNA (epegRNAs). 这些新的RNA显著提高了细胞中主要编辑效率,推进了基因编辑疗法.

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