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饮食中安托素摄入量,遗传风险和发生性性结肠炎:一项前性队列研究
Sishen Sun1, Danshu Wang1, Lintao Dan1,2
1Department of Gastroenterology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Phytotherapy research : PTR
|September 30, 2024
概括
较高的食安托西亚宁摄入量可能会降低人类炎症性肠病 (IBD),特别是性结肠炎 (UC) 的风险. 这种保护作用似乎在具有UC高遗传倾向的个体中更强.
科学领域:
- 营养科学 营养科学
- 胃肠病学 胃肠病学
- 流行病学 流行病学
背景情况:
- 动物研究表明,安东素有益于肠道健康.
- 缺乏人类证据将饮食中的安托西亚宁与炎症性肠病 (IBD) 预防联系起来.
- 囊括克罗恩病 (CD) 和性结肠炎 (UC) 的IBD是一个重大的健康问题.
研究的目的:
- 为了研究饮食中安东素摄入量与在大量人群中发展IBD的风险之间的关联.
- 通过对CD和UC的遗传易感性来探索这种关联的潜在修改.
主要方法:
- 使用来自188,044名无IBD个体的英国生物库数据的前性队列研究.
- 通过24小时的饮食回忆评估的安托西亚宁摄入量.
- 通过国家健康记录识别的IBD病例事件.
- 考克斯的比例回归模型用于分析关联,以基因风险得分进行调整.
主要成果:
- 较高的素摄入量与24%的IBD风险降低和35%的UC风险降低有关.
- 在安东素摄入量和克罗恩氏病 (CD) 风险之间没有观察到显著的关联.
- 抗生素和UC风险之间的反向关联在具有高遗传易感性UC的个体中更强.
结论:
- 饮食中较高的抗生素摄入量与IBD和UC的风险降低有关,但不是CD.
- 遗传因素可能会影响安东素对UC的保护作用.
- 需要进一步的研究来阐明潜在的机制.
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