拉脱维亚系统性硬化症队列的流行率和性别特定分析
Kristine Ivanova1,2,3, Olga Ribakova4, Anna Mihailova5,6
1Department of Doctoral Studies, Rīga Stradinš University, Riga, Latvia. kivanova1603@gmail.com.
Orphanet journal of rare diseases
|October 1, 2024
概括
系统性硬化症 (SSc) 在拉脱维亚的流行率低于欧洲其他地方,显示出南北梯度. 这项研究详细介绍了拉脱维亚SSc患者的人口统计和临床特征,并指出性别之间疾病表现的差异.
科学领域:
- 类风湿病学 类风湿病学
- 流行病学 流行病学
- 自免疫性疾病 自免疫性疾病
背景情况:
- 系统性硬化症 (SSc) 是一种严重的自身免疫性风湿性疾病.
- 在拉脱维亚,SSc的流行数据以前没有可用.
- 这项研究旨在调查拉脱维亚的SSc人口统计和临床数据.
研究的目的:
- 为了确定系统性硬化症 (SSc) 在拉脱维亚的患病率.
- 分析拉脱维亚SSc患者的人口和临床特征.
- 将SSc患者数据与欧洲现有的流行度梯度进行比较.
主要方法:
- 在2016年至2021年期间,在拉脱维亚两个主要医院咨询的SSc患者的回顾性研究.
- 数据收集包括人口统计信息,临床亚型,抗体存在和治疗.
- 2021年1月1日计算的点患病率.
主要成果:
- 确定了159名SSc患者;点患病率为百万分之一84.0.
- 女性与男性的比例为4.67:1,老年人群的比例更高.
- 男人表现出更广泛的疾病亚型和并发症;反核抗体是常见的,在特定的抗体模式中存在性别差异.
结论:
- 拉脱维亚的SSc患病率与欧洲南北梯度一致,这表明患病率较低.
- 在SSc的呈现和严重性方面观察到性别差异,特别是在老年人群中.
- 虽然抗核抗体很常见,但具体模式和疾病严重程度在性别之间存在差异;超过一半的患者常见地接受葡萄糖皮质激素治疗.
相关概念视频
01:43Sex-linked Disorders
Like autosomes, sex chromosomes contain a variety of genes necessary for normal body function. When a mutation in one of these genes results in biological deficits, the disorder is considered sex-linked.
01:18Factors Affecting Illness
When a person's physical, emotional, intellectual, social development or spiritual functioning is compromised, this deviation from a healthy normal state is called illness. Illness creates stress that in turn harms individuals. Irritation, anger, denial, hopelessness, and fear are behavioral and emotional changes an individual experiences in the phases of illness. A variety of factors influence a person's health and well-being.
For instance, risk factors are connected to illness, disability,...
For instance, risk factors are connected to illness, disability,...
01:29Bias in Epidemiological Studies
Biases can arise at various stages of research, from study design and data collection to analysis and interpretation. Recognizing and addressing these biases is essential to ensure the validity and reliability of epidemiological findings.Broadly speaking, biases in epidemiology fall into three main categories: selection bias, information bias, and confounding. A more detailed description of possible biases is:
01:23Rheumatic Heart Disease I: Introduction
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
01:22Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
01:19Multiple Sclerosis l: Introduction
Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...