在肺癌患者中,使用先进的放射学和深度学习来个性化预测免疫治疗反应
Chien-Yi Liao1,2, Yuh-Min Chen3,4, Yu-Te Wu5,6
1Department of Biomedical Imaging and Radiological Sciences, National Yang Ming Chiao Tung University, No. 155, Sec. 2, Linong Street, Beitou District, Taipei, 112, Taiwan.
概括
结合成像生物标志物和临床数据的新模型预测了接受免疫疗法 (IO) 的肺癌 (LC) 患者的无进展生存期 (PFS). 这种方法有助于个性化治疗,改善晚期LC的治疗结果.
科学领域:
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
- 医疗成像医学成像
背景情况:
- 肺癌 (LC) 是癌症死亡的主要原因之一.
- 免疫疗法 (IO) 对晚期LC有希望,但很难预测患者的反应.
- 确定将受益于IO的患者和监测治疗是至关重要的.
研究的目的:
- 在接受IO治疗的LC患者中开发无进展生存 (PFS) 的预测模型.
- 将先进的成像生物标志物 (放射学) 与临床特征集成,以改善预测.
- 为了提高个性化医疗策略在晚期肺癌.
主要方法:
- 对206名用IO治疗的LC患者的回顾性分析.
- 从治疗前的CT扫描中提取内和周血管辐射.
- 使用临床数据和放射性特征进行PFS预测的DeepSurv模型的开发.
主要成果:
- 结合放射学和临床特征,显著改善了IO反应的预测 (p < 0.001).
- DeepSurv模型实现了高性能,AUC为0.76-0.80和C指数为0.83.8的高性能.
- 预测的PFS曲线区分了有利和不利的预测 (p < 0.05).
结论:
- 将放射学和临床数据整合起来,可以创建一个强大的预测模型,用于IO上LC患者的PFS.
- 该模型能够估计个体PFS和预后,这有助于个性化医疗.
- 这种方法有望改善晚期肺癌治疗患者的治疗结果.
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