三级淋巴状结构的模式和预后价值在膜和膜的原发性腺癌
Minying Deng1, Xin Liu2, Yan Jiang1
1Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
World journal of surgical oncology
|October 1, 2024
概括
结核和结核腺癌中的三级淋巴状结构 (TLS) 被分析了存在,成熟度和预后价值. 在瘤边缘成熟的TLS与更长的无病存活率相关,这表明预测免疫疗法反应的潜力.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 病理学 病理学 病理学
背景情况:
- 三级淋巴体结构 (TLS) 越来越被认为对抗瘤免疫的重要性.
- 它们在原发性乳腺癌的作用 结核和结核仍然在很大程度上未被探索.
- 了解TLS特征可能有助于了解瘤进展和治疗反应.
研究的目的:
- 为了调查TLS的存在,位置和成熟度,在初级内和内腺癌中.
- 评估TLS与免疫治疗生物标志物的相关性,包括瘤突变负担 (TMB) 和微卫星不稳定性 (MSI).
- 为了确定TLS在这些罕见癌症患者的预后价值.
主要方法:
- 数字病理图像分析被用来对TLS进行分类和量化.
- 免疫组织化学评估了TLS成熟度.
- 下一代测序用于TMB和MSI分析,以及PD-L1表达评估.
主要成果:
- 内TLS (IT-TLS) 更常见的是未成熟的 (早期TLS),而二次卵泡状TLS (SFL-TLS) 主要是在侵袭边缘发现的.
- 高SFL-TLS密度与长期无病存活 (DFS) 相相关.
- 瘤突变负载高 (TMB-H) 与微卫星不稳定性高 (MSI-H) 有显著关联,并显示PD-L1表达的趋势.
结论:
- TLS存在于原发性结核和结核腺癌中,主要位于侵袭边缘和瘤外围.
- 成熟的TLS,特别是SFL-TLS,与更好的DFS有关,这表明它具有有利的预后作用.
- TMB,MSI和PD-L1之间的关联凸显了它们作为这些癌症免疫治疗的预测生物标志物的潜力.
关键词:
在MSI中,它是MSI.在PD-L1中.主要腺癌的阴和阴.在 TLS 中使用 TLS.TMB TMB TMB TMB TMB TMB TMB TMB TMB TMB TMB TMB TMB TMB TMB TMB TMB TMB TMB TMB更多相关视频
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