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相关概念视频

Autism Spectrum Disorder01:19

Autism Spectrum Disorder

74
Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
74
Modeling in Therapy01:26

Modeling in Therapy

56
Modeling, a key technique in therapy, uses observational learning to help clients acquire and practice new skills by watching therapists demonstrate desired behaviors. This approach, rooted in Albert Bandura's concept of vicarious learning, plays a significant role in therapeutic interventions for various psychological conditions, including social anxiety, ADHD, and depression.
Participant Modeling
Participant modeling involves therapists demonstrating calm and effective behaviors in...
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Theoretical Approaches to Psychological Disorder01:29

Theoretical Approaches to Psychological Disorder

117
The development of psychological disorders, which are characterized by deviant, maladaptive, and personally distressing behaviors, has been explored through several theoretical approaches.
Biological approach
The biological approach posits that internal, organic factors are the primary causes of such disorders. This perspective emphasizes brain structure and function, genetic predispositions, and neurotransmitter imbalances. For example, schizophrenia has been associated with both genetic...
117
The Nativist Approach01:21

The Nativist Approach

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The nativist approach to infant cognitive development proposes that infants are born with inherent knowledge structures that allow them to interpret the world almost immediately. This perspective contrasts with earlier developmental theories, such as those proposed by Jean Piaget, which emphasized a more gradual acquisition of cognitive abilities through interaction with the environment. One key concept in this approach is object permanence — the understanding that objects continue to...
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相关实验视频

Updated: Jun 11, 2025

A Novel Experimental and Analytical Approach to the Multimodal Neural Decoding of Intent During Social Interaction in Freely-behaving Human Infants
11:14

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Published on: October 4, 2015

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一个3D方法来理解早期发展自闭症的异质性.

Veronica Mandelli1, Ines Severino1,2, Lisa Eyler3,4

  • 1Laboratory for Autism and Neurodevelopmental Disorders, Center for Neuroscience and Cognitive Systems, Istituto Italiano di Tecnologia, Rovereto, Italy.

Molecular autism
|October 1, 2024
PubMed
概括

两种不同的自闭症亚型,I型和II型,通过早期功能 (LIMA) 特征来识别,显示不同的发育路径和生物标记. 这种分层可能会改善自闭症的预后和理解.

关键词:
集群集成是指集群集成.基因表达 基因表达 基因表达分层分层是指分层的分层.副类型 副类型 副类型功能磁力共振成像 (fMRI) 是一种功能共振成像.

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相关实验视频

Last Updated: Jun 11, 2025

A Novel Experimental and Analytical Approach to the Multimodal Neural Decoding of Intent During Social Interaction in Freely-behaving Human Infants
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科学领域:

  • 神经科学是一个神经科学.
  • 发展心理学 发展心理学
  • 遗传学 遗传学 是一个

背景情况:

  • 自闭症诊断目前使用一个单一的标签,忽视了早期功能中的显著的表型异质性.
  • 早期语言,智力,运动和适应性功能 (LIMA) 的关键差异特征区分了自闭症患者.
  • 基于LIMA特征的亚型化可以提供对自闭症多样化的发展轨迹和生物学更细致的理解.

研究的目的:

  • 根据早期的表型特征识别数据驱动的自闭症亚型.
  • 研究这些已识别的亚型的发育轨迹和生物学基础.
  • 评估基于LIMA的分类对改善自闭症分类和理解的潜力.

主要方法:

  • 在615名儿童的Mullen早期学习量表 (MSEL) 和Vineland适应性行为量表 (VABS) 数据上使用了无监督集群.
  • 使用来自国家心理健康研究所数据档案 (NDA) 和独立的UCSD数据集的数据检查了纵向发育轨迹.
  • 在UCSD队列的一个子集中分析了神经影像,基因表达和血液基因表达数据.

主要成果:

  • 根据早期LIMA特征,确定了两个强大的自闭症亚型 (I型和II型),准确率为98%.
  • 这些亚型在生命的第一个十年中表现出不同的发育轨迹.
  • 在功能和结构神经成像以及亚型之间的基因表达模式中观察到显著差异.

结论:

  • 根据LIMA特征将自闭症分为I型和II型的分层对预后和生物学理解具有潜在意义.
  • 这种分类方法突出了自闭症的不同发展路径和潜在的生物机制.
  • 需要使用更大的神经成像和基因表达数据集进行进一步的复制.