什么时候前列腺癌才是真正的癌症?
Matthew R Cooperberg1,2, Avery E Braun1, Alejandro Berlin3
1Department of Urology, UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, USA.
Journal of the National Cancer Institute
|October 1, 2024
概括
1级 (GG1) 前列腺癌 (PC) 可能不需要"癌症"标签,因为它具有惰的性质. 重新分类GG1可以减少过度治疗并改善患者的治疗结果.
科学领域:
- 在瘤学瘤学.
- 病理学 病理学 病理学
- 基因组学就是基因组学.
背景情况:
- 前列腺癌 (PC) 是全球癌症死亡的主要原因.
- 在讨论中,人们质疑将1级组 (GG1) PC归类为PC.
- 癌症 癌症 癌症 癌症 癌症
- 由于其惰的行为和缺乏转移潜力.
研究的目的:
- 召集国际利益相关者讨论GG1 PC.的分类.
- 探索将GG1 PC标记为"癌症"的含义.
- 确定降低PC死亡率的策略,同时尽量减少过度诊断和过度治疗的危害.
主要方法:
- 国际研讨会与各种利益相关者.
- 对尸检研究和空间转录学数据的审查.
- 讨论病理发现,诊断挑战和患者的观点.
主要成果:
- 尸体解剖研究表明,GG1 PC可能是许多男性衰老的正常方面.
- 纯GG1PC缺乏转移潜力;现代诊断经常错过它,将其归类为"偶然性瘤".
- 基因组分析揭示了变化的连续性,质疑传统癌症名称的任意性.
结论:
- GG1 PC 需要积极监测,但将其标记为"癌症"可能会造成不必要的患者负担和过度治疗.
- 讨论了一些替代标签,比如"状瘤".
- 修订GG1PC的分类可以通过减少过度诊断和过度治疗来改善公共卫生结果.
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