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远程自我管理的认知措施和阿尔茨海默病的成像生物标志物之间的持续联系

E A Boots¹, R D Frank, W Z Fan

¹Nikki H. Stricker, Ph.D., ABPP-CN, Mayo Clinic, 200 First Street SW, Rochester, MN 55905; 507-284-2649 (phone), 507-284-4158 (fax), stricker.nikki@mayo.edu (email).

The journal of prevention of Alzheimer's disease

|October 1, 2024

概括

梅奥试验车 (MTD) 显示了早期阿尔茨海默病 (AD) 检测的前景,与关键的成像生物标志物相关,并识别了风险人群中微妙的认知变化.

科学领域:

神经科学是一个神经科学.
老年学是一门学科.
医疗成像医学成像

背景情况:

早期发现阿尔茨海默病 (AD) 痴呆风险对于及时干预至关重要.
广泛的查需要可访问的,自我管理的认知评估.

研究的目的:

调查远程,自我管理的梅奥测试驱动器 (MTD) 认知评估和AD相关的成像生物标志物之间的关联.
评估MTD检测微妙认知变化的能力.

主要方法:

来自梅奥诊所衰老研究和AD研究中心684名成人的横截面研究.
参与者接受了粉样蛋白/蛋白PET扫描,MRI (海马体积,白质超强度),并完成了MTD和亲身神经心理评估.
多重回归分析了成像生物标志物和认知得分之间的关联.

主要成果:

较低的MTD性能与粉样蛋白/粉样蛋白 (PET) 负担增加,海马体积减少和较高的白质超强度相关.
在MTD测量中,认知正常 (CU) 和轻度认知障碍 (MCI) /痴呆症组之间存在显著差异.

结论:

梅奥试验车 (MTD) 证明了标准的有效性,与AD相关的成像生物标志物的持续测量相关.
MTD是一种简短的远程评估,能够检测主要是CU个体的微妙认知变化.

关键词:

数字健康数字健康梅奥医院进行了试驾.神经心理测试神经心理测试氨基化物氨基化物轻度的认知障碍轻度的认知障碍

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