肥胖促进了来自骨髓的髓状细胞的积累,而运动则减少了结肠癌中的增殖信号
James J Vanhie1, Lisa Ek Orloff1, Alice Tate1
1School of Human Kinetics, University of Ottawa, Ottawa, ON, CANADA.
Medicine and science in sports and exercise
|October 1, 2024
概括
运动训练 (EX) 通过抑制异常密室焦点 (ACF) 的形成,减少肥胖小鼠的结肠癌发病率. EX可能通过独立于髓状细胞积累的途径发挥作用,可能涉及降低β-catenin和STAT3信号传递.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 代谢过程中的代谢.
背景情况:
- 肥胖是结肠癌的一个已知的风险因素,可能与髓状细胞有关.
- 运动训练 (EX) 在预防结肠癌发病方面表现有前途.
- 早期髓状细胞积累和炎症在肥胖驱动的结肠癌发生中的确切作用以及EX的影响仍然不清楚.
研究的目的:
- 调查早期骨髓状细胞积累和炎症是否先于高脂肪饮食 (HFD) 诱导的肥胖和结肠癌发生.
- 为了确定EX是否可以减轻这些与肥胖有关的影响.
- 测试肥胖通过髓状细胞积累和炎症促进结肠癌发生的假设,EX可以减轻这种炎症.
主要方法:
- 给小鼠提供高脂肪饮食 (HFD) 或控制 (CON) 饮食8周.
- 小鼠接受阿佐西米 (AOM) 诱导结肠癌,并随机分配到运动 (EX) 或久坐 (SED) 条件.
- 分析了骨髓状细胞群,异常密室焦点 (ACF),β-catenin和STAT3蛋白水平.
主要成果:
- 由HFD引起的肥胖导致异常密室焦点 (ACF) 的形成增加,这是早期结肠癌发生的标志物.
- 与久坐状态相比,运动训练 (EX) 显著减少了ACF的形成.
- 虽然EX并没有改变结肠免疫细胞种群,但它降低了STAT3蛋白水平,并且与HFD小鼠中较高的β-catenin有关.
结论:
- 肥胖会促进结肠ACF的形成,这可能是早期炎症性髓状细胞积累的媒介.
- 运动训练 (EX) 减轻了ACF的形成,但没有改变结肠中髓状细胞的积累.
- 通过独立于髓状细胞调节的机制,EX可能会抑制结肠癌发生,可能涉及降低β-catenin和STAT3信号.
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