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患有良性性发性定位的患者的大脑功能变化表明视觉前庭交互和整合

Jing Wu¹, Liang Shu¹, Chen-Yan Zhou¹

¹Department of Neurology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Brain and behavior

|October 1, 2024

概括

在良性性定位 (BPPV) 患者的休息状态fMRI显示,视觉和感觉运动区域的大脑活动减少,小脑活动增加. 这些变化与头症状相关,可能表明适应性反应.

科学领域:

神经成像是一种神经成像.
神经科学是一个神经科学.
医疗成像医学成像

背景情况:

良性性发性位置性 (BPPV) 是一种常见的前体障碍.
重定位操作是BPPV的标准治疗方法.
了解BPPV的神经生物学基础及其恢复至关重要.

研究的目的:

分析静止状态功能磁共振成像 (rs-fMRI) 功能在BPPV患者的位置调整后.
调查这些rs-fMRI发现的临床相关性.
探索BPPV中大脑活动和功能连接的变化.

主要方法:

从38名BPPV患者和38名健康对照人群获得的rs-fMRI数据.
分析低频波动的振幅 (ALFF),分数ALFF (fALFF) 和百分比波动的振幅 (PerAF).
基于种子的功能连接 (FC) 分析和与临床头得分 (VAS,DHI) 的相关性.

主要成果:

在BPPV患者中,双侧尾叶的ALFF,fALFF和PerAF均降低.
在BPPV患者的小脑虫中观察到ALFF和fALFF的增加.
在特定区域减少的PerAF与头得分有负相关性;在前,叶和半中心叶之间观察到减少的FC.

结论:

在BPPV中自发的大脑活动的改变涉及头/额头双叶活动的减少以及小脑虫活动的增加.
关键大脑区域之间的功能连接减少表明网络集成中断.
观察到的功能变化可能反映了对残留的头和改变的感官处理的适应性反应.

关键词:

良性性发性定位性头.头叶的后半部分预先预测的情况静止状态功能磁共振成像技术视觉阴道相互作用.

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