在患有多发性硬化症的患者中评估缺食症 - 增加残疾负担的额外部分
Davide Ranucci1, Fabrizia Falco1, Valerio Nicolella1
1Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II, Naples, Italy.
Annals of clinical and translational neurology
|October 1, 2024
概括
消化不良 (吞困难) 影响了超过一半的多发性硬化症 (MS) 患者,通常不会被标准的临床尺度检测到. 吞障碍问卷 (SDQ) 有效地识别了这个问题,与MS的抑郁症和睡眠质量差相关.
科学领域:
- 神经学 神经学
- 胃肠病学 胃肠病学
- 临床评估 临床评估
背景情况:
- 多发性硬化症 (MS) 患者经常经历低估的症状,包括吞障碍 (吞困难).
- 扩展残疾状况尺度 (EDSS) 往往无法充分评估MS的消化不良.
- 早期识别食障碍对于管理MS进展和预防并发症至关重要.
研究的目的:
- 通过吞障碍问卷 (SDQ) 确定MS患者消化不良的患病率.
- 为了评估食障碍和EDSS之间的相关性.
- 调查MS中食障碍和临床人口学因素之间的关系.
主要方法:
- 177名多发性硬化患者使用EDSS,SDQ和认知功能,焦虑,抑郁,疲劳和睡眠质量测试进行了评估.
- 临床人口统计数据比较了患有和没有缺食症的患者.
- 本地EDSS得分与SDQ衍生的EDSS得分进行了比较.
主要成果:
- 通过SDQ,在56%的多发性硬化病患者中发现了缺食症,严重程度各不相同.
- 只有6名患者在他们的原生EDSS中发现了食障碍.
- SDQ-EDSS得分明显高于原生EDSS得分,表明标准尺度低估.
- 缺食症与抑郁症状和睡眠质量低下有显著的相关性.
结论:
- 在多发性硬化症患者中,缺食症非常普遍 (56%),并通过SDQ有效检测到.
- SDQ有助于评估疾病的进展,并预防诸如吸入性肺炎等并发症.
- SDQ-EDSS强调了本地EDSS在评估诸如食症之类的症状方面的局限性.
- 不消化症与抑郁症和睡眠不足的相关性表明,复杂的相互作用影响了MS症状的感知和潜在的疾病进展.
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