利兹美胺在治疗注意力缺陷多动症 (ADHD) 的有效性:元分析和综述
Heath Rutledge-Jukes1,2, Pallavi Jonnalagadda3, Andrew Paul McIntosh4
1Department of Psychiatry, Washington University School of Medicine, St. Louis, USA.
Cureus
|October 1, 2024
概括
利兹美胺二酸盐有效地治疗儿童和成人注意力缺陷/多动症 (ADHD) 症状. 这次元分析发现,在个人剂量或ADHD评分尺度-IV的子尺度之间,疗效没有显著差异.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 注意缺陷/多动障碍 (ADHD) 是一种流行的神经发育障碍.
- 利斯德克萨姆胺二甲基酸盐是一种常用于ADHD治疗的兴奋剂.
- 以前的分析没有在ADHD分级或单个剂量上区分治疗效应.
研究的目的:
- 进行关于lisdexamfetamine dimesylate对ADHD的疗效的元分析.
- 分析ADHD评分尺度-IV (ADHD-RS-IV) 的注意力缺失和过度活动子尺度上的治疗效应.
- 评估单个lisdexamfetamine dimesylate剂量对ADHD症状管理的影响.
主要方法:
- 2007年至2024年间发表的随机对照试验的系统元分析.
- 纳入标准:英语,使用ADHD-RS-IV的RCT用于儿童和成人的lisdexamfetamine疗效.
- 数据来源:MEDLINE,Embase,Cochrane,PubMed,clinicaltrials.gov.gov. 这些数据来源均来自美国.
主要成果:
- 与安慰剂相比,lisdexamfetamine dimesylate显著减轻了ADHD症状,基于完整的ADHD-RS-IV尺度.
- 在个别子尺度 (注意力不集中,过度活跃) 的疗效方面没有发现显著差异.
- 对单个剂量的分析显示,在不同剂量的ADHD症状管理中没有显著差异.
结论:
- 利斯德克萨姆胺二酸盐是儿童和成人群体中ADHD症状的有效治疗方法.
- 治疗疗效在不同剂量之间是一致的,并且在注意力不集中和过度活动子表之间没有显著差异.
- 该研究提供了详细的分析lisdexamfetamine dimesylate的疗效,剂量反应和ADHD管理中的子尺度效应.
关键词:
一个叫ADHD的孩子.这就是ADHD-RS-IV.成年人成年人成年人成年人成年人孩子们的孩子们的孩子们的孩子们.过度活跃症是一种过度活跃.缺乏注意力 缺乏注意力利斯德克萨姆胺二甲基酸.这是一个元分析.这些子级别的子级别.更多相关视频
05:48The Adventures of Fundi Intervention Based on the Cognitive and Emotional Processing in Attention Deficit Hyperactive Disorder Patients
Published on: June 12, 2020
5.7K
13:09Using Brain Activation nir-HEG/Q-EEG and Execution Measures CPTs in a ADHD Assessment Protocol
Published on: April 1, 2018
10.3K
相关概念视频
01:30Attention-Deficit/Hyperactivity Disorder
47
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
47
01:24CNS Stimulants: Cocaine, Amphetamines and Cannabinoids
167
CNS stimulants, such as cocaine, amphetamines, and cannabinoids, have varying structures and mechanisms of action that lead to different therapeutic effects and side effects. Cocaine, with its molecular formula C17H21NO4, is a tropane alkaloid and a tertiary amino compound. It has two chemical forms: the hydrochloride salt and the "freebase." The former is in powder form, while the latter involves removing the hydrochloride salt to create a form that can be smoked. Cocaine exerts its...
167
01:28Adrenergic Agonists: Mixed-Action Agents
678
Mixed-action adrenergic agonists, like ephedrine and pseudoephedrine, directly and indirectly affect adrenergic receptors. These agents stimulate adrenoceptors and indirectly release stored neurotransmitters, amplifying the adrenergic response.
Ephedrine and pseudoephedrine lack a catecholamine group, making them less susceptible to degradation by metabolic enzymes. They have increased oral bioavailability and lipophilicity, resulting in a longer duration of action. Their response is reduced by...
Ephedrine and pseudoephedrine lack a catecholamine group, making them less susceptible to degradation by metabolic enzymes. They have increased oral bioavailability and lipophilicity, resulting in a longer duration of action. Their response is reduced by...
678
01:25Adrenergic Agonists: Indirect-Acting Agents
1.5K
Indirect-acting adrenergic agonists potentiate the effects of endogenous catecholamines through different mechanisms without directly binding to adrenoceptors.
One mechanism involves depleting stored catecholamines by displacing them from synaptic vesicles. These agents, known as "displacers," are transported into vesicles at the expense of noradrenaline. Examples include amphetamine and tyramine, which lack a catechol moiety, resulting in prolonged action, improved oral...
One mechanism involves depleting stored catecholamines by displacing them from synaptic vesicles. These agents, known as "displacers," are transported into vesicles at the expense of noradrenaline. Examples include amphetamine and tyramine, which lack a catechol moiety, resulting in prolonged action, improved oral...
1.5K
01:30Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists
106
Cognitive enhancers, also known as "smart drugs," are substances used to enhance memory, mental alertness, and concentration. These can be natural or synthetic and improve cognition in conditions like Alzheimer's disease (AD) and other neurodegenerative diseases. Some common examples include caffeine, amphetamines, methylphenidate, modafinil, arecoline, donepezil, vortioxetine, and piracetam. These enhancers work on the principle of synaptic plasticity and altered circuit function.
106
01:22Alzheimer's Disease: Treatment
170
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
170