儿童淋巴结生物检查的淋巴腺病变的病因谱
Chandni Nawaz1, Mulazim Hussain2, Bilal Ahmad3
1Pediatric Surgery, Children's Hospital, Pakistan Institute of Medical Sciences, Islamabad, PAK.
Cureus
|October 1, 2024
概括
儿科淋巴腺病症通常是良性的,但可以表明严重的疾病. 这项研究发现结核病 (TB) 和淋巴瘤是儿童需要活检的最常见原因,这表明在流行地区进行有针对性的诊断.
科学领域:
- 儿童传染病 儿童传染病
- 手术病理学手术病理学
- 在瘤学瘤学.
背景情况:
- 儿科外围淋巴结核病通常是良性的,但可以表明严重的潜在疾病.
- 切除活检是儿童持续性淋巴腺病的关键诊断工具.
- 了解病因谱对于中低收入国家的适当管理至关重要.
研究的目的:
- 通过切除活检诊断的持续的儿科淋巴腺病变的原因.
- 为此群体推优化评估,诊断测试和手术干预.
- 分析GeneXpert和PPD结核病测试的诊断效用.
主要方法:
- 这是一项针对243名患有淋巴腺病症超过4周的儿科患者 (1-12岁) 的前性横截面研究.
- 收集的数据包括人口统计数据,临床症状/征兆和本病理学发现.
- 对诊断测试结果 (GeneXpert,PPD) 的分析和淋巴结位置与诊断的关联.
主要成果:
- 结核病 (33.7%) 和淋巴瘤 (10.3%) 是反应性增生 (40.3%) 之后最常见的诊断.
- 宫淋巴腺病是最常见的; 关节与淋巴瘤有关 (p=0.008).
- 唾液GeneXpert显示结核病的真阳性率为78.84%;PPD仅在13名结核病患者中呈阳性.
结论:
- 结核病和淋巴瘤是导致持续的儿科淋巴结核病的主要原因,需要活检.
- 经验性结核病治疗可能会被认为是积极的GeneXpert和临床怀疑在特有地区,可能避免活检.
- 切除活检仍然是黄金标准,但更少的侵入性诊断算法需要进一步的研究.
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