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在 temporomandibular关节骨关节炎中,微阵列分析了炎症和底骨中的血管生成之间的信号相互作用

Wenpin Qin¹, Jialu Gao¹, Jianfei Yan¹

¹Department of Stomatology, Tangdu Hospital & State Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration & School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi Province, China.

Biomaterials translational

|October 1, 2024

概括

骨关节炎 (OA) 疼痛与炎症和新血管生长 (血管生成) 相关. 关键的信号通路和基因如Pi3kcd,Camp,Cxcr4和Myb相互作用,为OA缓解疼痛提供了潜在的目标.

科学领域:

分子生物学分子生物学
病理学病理学病理学
遗传学遗传学是一个

背景情况:

骨关节炎 (OA) 的特点是炎症和血管生成,这与关节疼痛有关.
导致OA疼痛的亚冠骨内特定的信号相互作用仍然不清楚.

研究的目的:

为了研究炎症和血管新生之间的信号相互作用,在骨关节性关节的亚冠状骨.
为了确定潜在的分子标来抑制OA.

主要方法:

开发一个单边前部交叉咬伤小鼠模型,用于研究关节OA和关节OA.
基于微阵列的转录组分析和定量实时聚合酶链反应,以识别差异表达基因 (DEG).
丰富分析 (基因本体学,KEGG通路) 和蛋白质与蛋白质相互作用分析.

主要成果:

鉴定了182个差异表达基因 (DEG),其中168个是上调的,14个是下调的.
丰富分析强调炎症 (T细胞激活,mTOR/NF-κB/TNF信号传递) 和血管新生 (血管新生调节,血管发育,PI3K-Akt/VEGF/HIF1信号传递) 受到显著影响.
确定了关键的相互作用基因,包括Pi3kcd,Camp,Cxcr4和Myb.

结论:

炎症和血管新生之间的信号相互作用在骨关节性关节的下丘脑骨中相互关联.
这些相互作用与OA疼痛的外周起源有关.
已识别的基因和途径代表了OA疼痛管理的潜在治疗标.

关键词:

血管新生的产生.这是一种炎症炎症炎症炎症.骨关节炎疼痛骨关节炎疼痛骨关节炎是一种关节炎.底骨的骨头底骨的骨头关节 (TMJ) 是一个关节.

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