在接受化疗的少数癌症患者中测试基于家庭的运动策略 (THRIVE试验):研究协议
Huimin Yan1, Paola Gonzalo-Encabo2,3, Rebekah L Wilson2,4
1Department of Exercise and Health Sciences, Manning College of Nursing and Health Sciences, University of Massachusetts Boston, Boston, MA, United States.
Frontiers in oncology
|October 1, 2024
概括
这项研究研究了一项针对接受化疗的少数癌症患者的家庭炼计划,旨在改善身体活动并降低心血管风险. 这些研究结果将为未来对不同癌症患者群体的运动干预措施的试验提供信息.
科学领域:
- 运动瘤学运动瘤学
- 预防心血管疾病 预防心血管疾病
- 癌症护理中的健康差异
背景情况:
- 与白人患者相比,西班牙裔/拉丁裔和黑人癌症患者在化疗期间表现出更高的身体不活动和并发症率.
- 少数群体和弱势群体在癌症炼临床试验中的参与率很低,尽管炼有好处.
- 这项研究解决了少数癌症人群中可访问的运动干预措施的需求.
研究的目的:
- 检查一种新的,可访问的,在家进行的运动干预措施对运动参与和心血管疾病风险的影响.
- 对少数癌症患者进行监督和无监督的家庭炼的影响进行调查.
- 在这个人群中探索运动参与的生物和行为机制.
主要方法:
- THRIVE试验是一个为期8个月的三臂研究,随机分配45名患者 (乳腺癌,结肠直肠癌,前列腺癌) 接受监督 (SUP),无监督 (UNSUP) 家庭炼或注意力控制 (AC).
- 干预措施包括16周的周期性有氧和抵抗计划 (SUP/UNSUP) 或拉伸 (AC),SUP利用视频会议.
- 主要结局是身体活动的变化 (加速计);次要结局包括心血管风险因素和身体功能.
主要成果:
- 主要结局:通过介入后的加速度计来评估体育活动数分钟的变化.
- 二次结果:心血管风险因素的变化,患者报告的结果和身体功能.
- 在基线收集的数据,4个月 (干预后) 和8个月 (随访).
结论:
- 这项THRIVE试验开创了一个潜在的可实现的运动干预措施,用于接受化疗的少数癌症患者.
- 结果将为大规模的随机对照试验提供有关家庭炼有效性的信息.
- 这项研究旨在改善治疗结果,降低服务不足的癌症患者群体的并发性疾病风险.
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