胃癌患者有明显出血的系统治疗:倾向性得分匹配分析
Yan-Hong Yao1,2, Hua Zhang3, Yu Xiao1
1Department of Medical Oncology and Radiation Sickness, Peking University Third Hospital, Beijing 100191, China.
World journal of clinical oncology
|October 1, 2024
概括
在胃癌 (GC) 患者治疗前出现过度出血 (OB) 并没有影响存活率或不良事件. 然而,治疗后明显出血 (OBAT) 与GC/胃食道结癌 (GEJC) 患者的整体存活率较差有关.
科学领域:
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
背景情况:
- 流血是胃癌 (GC) 和胃食道结癌 (GEJC) 患者的已知并发症,通常与预后不佳有关.
- 没有先前的研究评估了GC/GEJC患者的初始化疗的疗效和安全性,这些患者经历了明显出血 (OB).
研究的目的:
- 评估明显出血 (OB) 对晚期或转移性GC/GEJC患者的生存结果和与治疗相关的不良事件 (TRAE) 的影响.
- 为了比较治疗前 (OBBT) 和治疗后 (OBAT) 明显出血和没有出血的患者之间的结果.
主要方法:
- 在北京大学第三医院治疗的晚期或转移性GC/GEJC患者的回顾性分析.
- 倾向性得分匹配 (PSM) 分析用于平衡不同组之间的患者特征.
主要成果:
- 在PSM之后,分析了32名OBBT患者和61名没有OBBT的患者. 疾病控制率和TRAE在各组之间是相似的.
- 患有OBBT的患者 (15.2个月) 与没有OBBT的患者 (23.7个月) 的平均整体存活期 (mOS) 是可比的.
- 然而,与没有OBAT (23.7个月) 患者相比,在OBAT患者 (11.4个月) 中,mOS显著恶化.
结论:
- 在治疗前有明显出血的GC/GEJC患者的初始化疗 (OBBT) 与没有OBBT的患者相比,显示出相似的存活率和安全性.
- 治疗后发生的过度出血 (OBAT) 与GC/GEJC患者的整体存活率较差有关,这凸显了治疗后管理出血的重要性.
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