巴基斯坦人口中脂蛋白测试的频率和水平
Hijab Batool1, Madeeha Khan2,3, Quratul Ain2,4
1Chemical Pathology, Chughtai Institute of Pathology, Lahore, Pakistan.
Global cardiology science & practice
|October 1, 2024
概括
脂蛋白[Lp[a]检测在巴基斯坦并不常见,尽管它在动脉样硬化心血管疾病 (ASCVD) 中发挥了作用. 很大一部分被测试的人,特别是年轻人,表现出升高的Lp (a) 水平,这表明公共卫生问题.
科学领域:
- 心脏病学 心脏病学
- 临床生物化学 临床生物化学
背景情况:
- 脂蛋白 (Lp) 是一种关键的动脉质粒子,也是动脉样硬化心血管疾病 (ASCVD) 的独立风险因素.
- 了解Lp (a) 测试频率和高水平的患病率对于在不同人群中评估心血管风险至关重要.
研究的目的:
- 为了确定在巴基斯坦的脂质蛋白 (Lp) 测试频率.
- 评估巴基斯坦人口中升高Lp (a) 水平的发病率.
主要方法:
- 一项观察性研究分析了5年 (2015年6月 - 2020年10月) 1060名患者的Lp(a) 和脂质资料数据.
- 统计分析包括Kruskal-Wallis和Spearman相关性,以评估Lp (a) 水平,年龄和脂质变量之间的关联.
主要成果:
- 在五年内,仅进行了1060次Lp(a) 测试,平均每年212次.
- 37.2%的测试个体的Lp (a) 水平≥30 mg/dL,年轻个体的水平更高.
- 没有发现基于性别的显著差异,而Lp (a) 与其他脂质标志物的相关性很弱.
结论:
- 尽管Lp(a) 在ASCVD中发挥了既定的作用,但巴基斯坦的检测率显著低.
- 测试的巴基斯坦人口中有很大比例的Lp (a) 水平升高,突出了心血管风险管理中的潜在差距.
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