儿童自身免疫艾迪逊病的多重面孔
Donatella Capalbo1, Andrea Esposito2, Valeria Gaeta1
1Pediatric Endocrinology Unit, Department of Translational Medical Sciences, University of Naples Federico II, Naples, Italy.
Frontiers in endocrinology
|October 1, 2024
概括
初级上腺功能衰竭 (PAI) 是一种罕见的,危及生命的疾病. 本综述侧重于儿童自身免疫性PAI,旨在改善早期诊断和管理这种日益公认的原因.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 自免疫性疾病 自免疫性疾病
- 上腺腺疾病 上腺疾病
背景情况:
- 初级上腺功能缺陷 (PAI) 是一种罕见但严重的疾病,由于上腺激素缺乏.
- 虽然先天性缺陷在儿童中很常见,但自身免疫性是儿童群体中PAI的新兴原因.
- 目前关于儿童自身免疫PAI的数据有限,需要进一步调查.
研究的目的:
- 审查当前关于儿童自身免疫PAI病因,临床表现和治疗的知识.
- 提高医生对儿科患者自身免疫性PAI的临床症状的认识.
- 解决儿科自身免疫性PAI的诊断挑战和知识差距.
主要方法:
- 对儿童自身免疫性PAI现有研究的文献综述.
- 综合有关流行病学,临床表现和治疗策略的数据.
- 对导致儿科自身免疫性PAI诊断延迟的因素的分析.
主要成果:
- 自免疫被确定为儿童PAI的第二大常见原因.
- 在儿科病例中,非特异性症状往往导致自身免疫性PAI的延迟诊断.
- 了解儿童自身免疫性PAI的特征对于及时干预至关重要.
结论:
- 儿童自身免疫性PAI需要增加临床怀疑和意识.
- 需要进一步的研究来确定儿科自身免疫PAI的流行病学和长期结果.
- 及时识别和适当的管理对于改善自身免疫PAI儿童的结果至关重要.
相关概念视频
Adrenal Gland Disorders
1.4K
Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
1.4K
Autoimmune Disorders
394
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
Concept and Mechanism of Autoimmune Diseases
The immune...
394
Immunodeficiency Diseases
916
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
There are three main causes of immunodeficiency...
916
Hormones of the Adrenal Glands
2.3K
Adrenal hormones play a pivotal role in maintaining the body's electrolyte balance and orchestrating responses to stress, showcasing the intricate functions of the adrenal cortex and medulla.
The adrenal cortex, a powerhouse of hormone synthesis, generates over two dozen corticosteroid hormones. The zona glomerulosa produces mineralocorticoids, exemplified by aldosterone, influencing the electrolyte composition of body fluids. The synthesis of glucocorticoids such as cortisol and...
The adrenal cortex, a powerhouse of hormone synthesis, generates over two dozen corticosteroid hormones. The zona glomerulosa produces mineralocorticoids, exemplified by aldosterone, influencing the electrolyte composition of body fluids. The synthesis of glucocorticoids such as cortisol and...
2.3K
What is the Immune System?
110.9K
Overview
110.9K
Anatomy of the Adrenal Glands
2.0K
The adrenal or supra-renal glands, situated above the kidneys and aligned with the twelfth rib, are paired pyramid-shaped structures crucial for the body's stress response. During stress, these glands secrete hormones vital for adaptive physiological reactions.
These glands possess a distinctive yellow tinge due to the stored cholesterol and fatty acids required for hormone synthesis. They are encased in a fibrous capsule and cushioned by fat.
The adrenal gland comprises two distinct...
These glands possess a distinctive yellow tinge due to the stored cholesterol and fatty acids required for hormone synthesis. They are encased in a fibrous capsule and cushioned by fat.
The adrenal gland comprises two distinct...
2.0K


