在美国成年人中,残留胆固醇和严重的腹腔大动脉化之间的性别相关性
Laisha Yan1, Xiaoyan Hu1, Shanshan Wu1
1Department of Cardiosurgery Intensive Care Unit, Ningbo Medical Centre Li Huili Hospital, Ningbo, China.
Frontiers in endocrinology
|October 1, 2024
概括
较高的残留胆固醇 (RC) 水平显著增加女性严重腹腔大动脉化 (AAC) 的风险. 这种关联在男性中没有观察到,这表明RC和AAC患病率之间存在性别特异性联系.
科学领域:
- 心血管研究的心血管研究.
- 代谢健康 代谢健康
- 流行病学 流行病学
背景情况:
- 剩余胆固醇 (RC) 是已知的心血管疾病风险预测因素.
- RC与各种健康状况有关,包括高血压和肝脏疾病.
- RC和腹部大动脉化 (AAC) 之间的关系仍然未被探索.
研究的目的:
- 调查残留胆固醇 (RC) 与严重腹腔大动脉化 (AAC) 的患病率之间的相关性.
- 检查RC和严重AAC之间的关联中潜在的性别差异.
主要方法:
- 从2013-2014年国家健康和营养检查调查 (NHANES) 的数据进行横截面分析.
- 使用多重逻辑回归和通用总和模型.
- 进行了子组分析和值效应分析,以评估RC-AAC关系.
主要成果:
- 在女性参与者中,RC和严重的AAC之间发现了显著的正相关性.
- 在男性参与者中,没有观察到RC和严重AAC之间的显著相关性.
- 与严重的AAC相关的性别和RC之间的显著相互作用被确定 (P=0.0042).
结论:
- 升高的残留胆固醇 (RC) 水平与女性严重腹腔大动脉化 (AAC) 的患病率增加显著相关.
- 这些发现突出了RC和AAC之间的性别特异关系.
- 进一步的研究可能会阐明这种观察到的性别差异背后的机制.
相关概念视频
Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT
3
Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
3
Cholesterol: Significance and Regulation
519
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Considering cholesterol and...
519
Coronary Artery Disease I: Introduction
3
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
3
Imaging Studies for Cardiovascular System III: X-Ray
150
The most common cardiovascular diagnostic test is an X-ray. It produces images of the heart, blood vessels, and adjacent structures.
Definition and Purpose
An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...
Definition and Purpose
An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...
150
Atherosclerosis II: Clinical manifestations and prevention
2
Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
2
Aneurysm II: Clinical Manifestations and Diagnostic Studies
3
Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
3


