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Updated: Jun 25, 2026

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利用非编码区域来保证基于小型面板的瘤突变负担估计的准确性

Takahiro Nishino1, Mio Yumura2, Kuniko Sunami1,3

  • 1Department of Laboratory Medicine, National Cancer Center Hospital, Tokyo, Japan.

Cancer science
|October 1, 2024
PubMed
概括

将非编码区域纳入瘤突变负担 (TMB) 计算可以提高小基因组的准确性. 这种使用OncoGuide NCC Oncopanel System (NOP) 的增强的TMB估计更好地与整个外因组测序和FoundationOne®CDx测试保持一致.

关键词:
癌症基因组医学 癌症基因组医学基因组测试组测试非编码地区地区.精确瘤学 精确瘤学瘤突变负担的突变负担

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Area Problem01:26

Area Problem

Determining the area of a region with straight edges is straightforward, as geometric formulas for rectangles, triangles, and polygons can be applied directly. However, traditional geometric methods are insufficient when a region has a curved boundary, such as the area under a function.fromThe area problem involves finding a systematic way to measure such regions. One approach to solving this problem is through approximation. Instead of attempting to compute the area exactly at the outset, the...