卡切西亚和一线系统治疗对先前未经治疗的高级非小细胞肺癌的影响:NEJ050A
Keita Miura1, Takehito Shukuya1, Naoki Furuya2
1Department of Respiratory Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Journal of cachexia, sarcopenia and muscle
|October 1, 2024
概括
卡切西亚影响了近三分之一的晚期非小细胞肺癌 (NSCLC) 患者. 治疗类型会影响这些患者的生活质量和生存结果.
科学领域:
- 在瘤学瘤学.
- 癌症研究 癌症研究
- 临床试验 临床试验
背景情况:
- 癌症缓冲症是晚期非小细胞肺癌 (NSCLC) 的常见并发症.
- 缓解症的频率和对NSCLC一线全身治疗结果的影响尚不清楚.
研究的目的:
- 调查先前未经治疗的先进NSCLC患者接受一线治疗的缓解症的发病率.
- 根据不同的治疗方式,评估缓解症对生活质量 (QOL),体重 (BW) 变化和生存结果的影响.
主要方法:
- 一项多中心,前性观察性研究招募了887名未经治疗的晚期NSCLC患者 (ECOG PS 0-2) 患有白血病.
- 患者接受了第一线全身治疗:向治疗,细胞毒性化疗 (CTx) ±免疫检查点抑制剂 (ICI),或单独使用ICI.
- 测量结果包括功能性厌食症/食症治疗评估 (FAACT) 评分,QOL,BW变化,无进展生存期 (PFS) 和整体生存期 (OS).
主要成果:
- 在31.7% (281/887) 的患者中,卡赫西亚存在.
- 与食欲相关的QOL趋势因治疗队列而异,CTx影响早期QOL.
- 与CTx±ICI或单独ICI相比,向治疗显示出更好的PFS和OS.
结论:
- 卡切西亚影响了大约三分之一的晚期NSCLC患者.
- 第一线治疗选择会影响卡切克性NSCLC患者的QOL和存活率.
- 向治疗在这个人群中显示出更好的生存益处.
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