患有输血依赖性沙拉西米亚的儿童的甲状腺状况在三级医院的三级医院
J Ferdousi1, R Parveen, S K Dhar
1Dr Jannatul Ferdousi, Department of Paediatrics, Mymensingh Medical College Hospital, Mymensingh, Bangladesh;
Mymensingh medical journal : MMJ
|October 1, 2024
概括
患有输血依赖性沙拉西米亚的儿童通常会因为输血导致的铁过载而患上甲状腺功能低下症. 这项研究发现这些儿童的亚临床甲状腺功能低下率显著更高,与血清费里水平升高有关.
科学领域:
- 儿科 儿科 儿科
- 内分泌学 在内分泌学.
- 血液学 血液学 血液学
背景情况:
- 孟加拉国常见的输血依赖性血症,由于缺乏化疗法,往往导致铁过载.
- 在甲状腺中积累的铁可以导致甲状腺功能障碍的thalassemic患者.
研究的目的:
- 评估患有输血依赖性沙拉西米亚的儿童的甲状腺状况.
- 在这个人群中调查铁过载和甲状腺功能障碍之间的关联.
主要方法:
- 一项横截面分析研究,将60名患有thalassemia的儿童 (3-12岁) 与60名没有thalassemia的对照进行比较.
- 测量了血清自由甲状腺素 (FT4),甲状腺刺激激素 (TSH) 和费里水平.
- Hb电泳证实了血病诊断;SPSS 21.0 版本用于数据分析.
主要成果:
- 与对照组相比,患有thalassemia的儿童的血清FT4水平显著降低,TSH水平较高 (p < 0.05).
- 亚临床的甲状腺功能低下症在患有甲状腺素的儿童 (25.0%) 与对照组 (3.3%) (p = 0.001) 中明显更为普遍.
- 较高的血清费里水平显着与thalassemic患者的甲状腺功能低下有关,费里和TSH之间存在正相关性 (p < 0.001).
结论:
- 患有输血依赖性沙拉西米亚的儿童患甲状腺功能低下症的风险明显更高.
- 铁过载,如血清费里水平升高,与这些儿童甲状腺功能低下症的发展密切相关.
- 定期监测甲状腺功能对于接受输血的血儿童至关重要.
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