在接受单侧部分切除术的患者中,手术内给予德克斯梅德托米丁和急性损伤:一项回顾性研究
Ryan Wong1, Juan Jose Guerra-Londono2,3, Arun Muthukumar2,3
1Tilman J. Fertitta Family College of Medicine, University of Houston, Houston, Texas, USA.
Renal failure
|October 1, 2024
概括
在经过部分切除术的患者中,手术内用德克斯梅德托米丁并没有降低急性损伤 (AKI) 风险. 这项研究发现,接受德克斯梅德托米丁和不接受德克斯梅德托米丁的患者之间的AKI率没有显著差异.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 麻醉学 麻醉学
- 外科手术的结果
背景情况:
- 部分切除术增加了急性损伤 (AKI) 的风险.
- 德克斯梅德托米丁是一种潜在的药物,可以改善脏的结果.
- 调查德克斯梅德托米丁对脏切除术后AKI的影响至关重要.
研究的目的:
- 为了确定手术内用德克斯梅德托米丁是否可以降低单边部分切除术后的AKI发病率.
- 分析德克斯梅德托米丁与术后结局之间的关联.
主要方法:
- 对1632名接受单边部分切除术的成年患者进行了回顾性研究 (2016年4月 - 2023年10月).
- 根据手术内给予德克斯梅德托米丁的情况,患者被分组.
- 倾向性得分匹配 (PSM) 调整了诸如年龄,BMI,ASA得分和缺血时间等混因素.
主要成果:
- 在PSM之前,AKI的发病率为31.2% (使用德克斯梅丁) 和25.7% (不使用德克斯梅丁).
- 在PSM之后,AKI的发病率为31.3% (用德克塞米丁) 和27.6% (不使用德克塞米丁).
- 德克斯梅德托米丁与AKI的几率比为0.910 (p=0.677),表明没有显著的关联.
结论:
- 经过单侧部分切除术后,手术内给予德克斯梅德托米丁与AKI的发病率或严重程度的降低无关.
- 可能需要进一步的研究来探索其他脏保护策略.
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