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Updated: Jun 11, 2025

Atomic Force Microscopy Investigations of DNA Lesion Recognition in Nucleotide Excision Repair
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Published on: May 24, 2017

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N2-Alkyl-dG病变引起了基因组中的R循环积累

Yinan Wang1, Feng Tang1, Ting Zhao2

  • 1Department of Chemistry, University of California, Riverside, CA 92521-0403, USA.

Nucleic acids research
|October 1, 2024
PubMed
概括

通过增加R循环积累,DNA化剂会导致基因组不稳定. 未修复的N2-alkyl-dG病变会破坏转录并损害基因组完整性,这表明R环酶抑制剂作为治疗策略.

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