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服用口服维生素D补充剂,适用于接受减肥手术的肥胖成年人
Marlene T Chakhtoura1,2, Nancy F Nakhoul2,3, Elie A Akl4,5
1Calcium Metabolism and Osteoporosis Program, WHO Collaborating Center for Metabolic Bone Disorders, American University of Beirut Medical Center, Beirut, Lebanon.
The Cochrane database of systematic reviews
|October 1, 2024
概括
减肥手术后的维生素D补充剂显示了改善维生素D水平的潜力,但关于最佳剂量和骨折预防的证据仍然有限. 进一步的研究对于基于证据的指导方针至关重要.
科学领域:
- 内分泌学 在内分泌学.
- 营养科学 营养科学
- 手术科学 手术科学
背景情况:
- 维生素D缺乏是常见的腹部外科手术后,可能会影响骨健康.
- 目前关于补充维生素D的指导方针缺乏可靠的证据.
- 在这个人群中,维生素D的最佳剂量和益处是未知的.
研究的目的:
- 为了比较低,中等和高剂量维生素D补充剂与安慰剂在接受减肥手术的成年人中的影响.
- 评估对骨健康和相关结果的影响.
主要方法:
- 在多个数据库 (CENTRAL,MEDLINE,Embase,LILACS) 和试验注册表中进行系统搜索.
- 包括随机对照试验和对照临床试验.
- 评估主要结果 (骨折,不良事件) 和次要结果 (维生素D状态,死亡率,骨矿物质密度等) 的评估. 使用GRADE方法.
主要成果:
- 适量维生素D (3200 IU/天) 与安慰剂相比,可以改善维生素D状态,证据确定性低.
- 高剂量维生素D (每天超过3500 IU) 可能会增加25-氧维生素D水平,相比中等剂量,但证据非常不确定.
- 没有关于骨折的试验报告;对高剂量补充剂的不良事件的证据稀缺且不确定.
结论:
- 有限的证据表明,中等剂量的维生素D可以改善腹腔外科手术后的维生素D状况.
- 高剂量维生素D对维生素D水平和副甲状腺激素的影响尚不确定.
- 需要进一步的研究来确定最佳的维生素D剂量,以预防腹骨折,并确定腹手术患者的安全性.
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