Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Mutations01:39

Mutations

Overview
Mutations01:35

Mutations

Mutations are changes in the sequence of DNA. These changes can occur spontaneously or they can be induced by exposure to environmental factors. Mutations can be characterized in a number of different ways: whether and how they alter the amino acid sequence of the protein, whether they occur over a small or large area of DNA, and whether they occur in somatic cells or germline cells.
Chromosomal Alterations Are Large-Scale Mutations
While point mutations are changes in a single nucleotide in...
Mutations in Microorganisms01:18

Mutations in Microorganisms

Mutations are heritable changes in an organism’s genome involving alterations in the base sequence of DNA or RNA. These changes can influence cellular processes and phenotypic traits, potentially transforming the unaltered wild type into a mutant form. Such changes, termed forward mutations, are pivotal in shaping the genetic diversity of organisms.RNA viruses exhibit the highest mutation rates due to the absence of robust proofreading mechanisms during genome replication. In contrast,...
Determinants of Bacterial Pathogenicity and Virulence01:20

Determinants of Bacterial Pathogenicity and Virulence

Pathogenic bacteria employ a variety of strategies to establish infections, including the secretion of extracellular enzymes that act as potent virulence factors. These enzymes facilitate bacterial colonization of host tissues and help evade immune surveillance. By targeting structural components of host tissues and interfering with immune mechanisms, these enzymes play a pivotal role in disease progression.Extracellular Enzymes Facilitating Tissue Invasion: Several bacterial pathogens secrete...
Regulation of Bacterial Virulence01:28

Regulation of Bacterial Virulence

Pathogenic bacteria employ a range of regulatory mechanisms to modulate the expression of virulence genes in response to environmental and host-derived signals. These mechanisms ensure that virulence factors are expressed only under favorable conditions, thereby optimizing infection and survival strategies.Mechanisms of Virulence RegulationKey regulatory strategies include:Two-Component Systems: These consist of a membrane-bound sensor kinase and a cytoplasmic response regulator. Environmental...
Bacterial Gastroenteritis01:18

Bacterial Gastroenteritis

Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid receptor...

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Met32 governs transcriptional control of sulfur metabolic flexibility and resistance to reactive sulfur species in the human fungal pathogen <i>Candida albicans</i>.

mBio·2026
Same author

Impact of differential dietary concentrations of cobalt, manganese and zinc on gastrointestinal microbiome and resistome of lactating dairy cattle.

Animal microbiome·2026
Same author

Polysialic acid is associated with immune activation in human peripheral blood nuclear cells.

Glycobiology·2026
Same author

Three <i>Staphylococcus</i> Bacteriophages Isolated from Swine Farm Environment in Quebec, Canada, Infecting <i>S. chromogenes</i>.

Viruses·2026
Same author

Complete Genome Sequence of <i>Pithoascus kurdistanensis</i> CBS 149789, an Endophytic Fungus Isolated from <i>Papaver bracteatum</i>.

Journal of fungi (Basel, Switzerland)·2025
Same author

Androgenic effects of 11-oxyandrogens in castration-resistant prostate cancer.

BMC cancer·2025

相关实验视频

Updated: Jul 17, 2026

A Tandem Liquid Chromatography&#8211;Mass Spectrometry-based Approach for Metabolite Analysis of Staphylococcus aureus
08:03

A Tandem Liquid Chromatography–Mass Spectrometry-based Approach for Metabolite Analysis of Staphylococcus aureus

Published on: March 28, 2017

10.1K

特定的氨基酸变化与致病性黄状细菌相关.

Vincent Gélinas1,2, Valérie E Paquet1,2,3, Maude F Paquet1,2

  • 1Institut de Biologie Intégrative et des Systèmes (IBIS), Université Laval, Quebec City, QC G1V 0A6, Canada.

Genome
|October 1, 2024
PubMed
概括

在Flavobacterium细菌中的特定氨基酸变化可能解释了它们适应鱼类的情况. 这些CII类的变化与复制和修复功能有关,可能导致鱼类的病原性.

关键词:
这是一种Flavobacterium菌.适应 适应 适应 适应核心蛋白质的变化 核心蛋白质的变化鱼的病原体 鱼的病原体基因丰富是一种基因丰富.人类的基因组学.

更多相关视频

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation
07:15

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation

Published on: January 16, 2019

10.9K
A Fluorescence-based Method to Study Bacterial Gene Regulation in Infected Tissues
07:10

A Fluorescence-based Method to Study Bacterial Gene Regulation in Infected Tissues

Published on: February 19, 2019

8.8K

相关实验视频

Last Updated: Jul 17, 2026

A Tandem Liquid Chromatography&#8211;Mass Spectrometry-based Approach for Metabolite Analysis of Staphylococcus aureus
08:03

A Tandem Liquid Chromatography–Mass Spectrometry-based Approach for Metabolite Analysis of Staphylococcus aureus

Published on: March 28, 2017

10.1K
Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation
07:15

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation

Published on: January 16, 2019

10.9K
A Fluorescence-based Method to Study Bacterial Gene Regulation in Infected Tissues
07:10

A Fluorescence-based Method to Study Bacterial Gene Regulation in Infected Tissues

Published on: February 19, 2019

8.8K

科学领域:

  • 微生物学 微生物学
  • 基因组学就是基因组学.
  • 进化生物学 进化生物学

背景情况:

  • *Flavobacterium*属包括全球各地在各种环境中发现的多种微生物.
  • 某些类型的 *Flavobacterium*,如 *F. psychrophilum* 和 *F. columnare*,导致水产养殖业的重大疾病和经济损失.
  • 导致Flavobacterium鱼类致病性的进化途径和驱动鱼类殖民的特定蛋白质变化仍然在很大程度上是未知的.

研究的目的:

  • 为了研究鱼类致病性 *Flavobacterium* 种类的进化起源.
  • 为了确定与鱼类的适应和殖民相关的特定蛋白质变化,由*Flavobacterium*.

主要方法:

  • 用861个软核基因对208种*Flavobacterium*种类进行了家族遗传学分析.
  • 在特定类别内识别保存的氨基酸变化.

主要成果:

  • 遗传学分析确定了一个分类 (CII) 包含九种物种,包括五种鱼类病原体和大多数鱼类殖民物种.
  • 在CII类中的11种蛋白质中保存了13种特定的氨基酸变化.
  • 这些蛋白质主要参与复制,重组和修复,在细菌的致病性和适应性中有一些已知的作用.
  • 观察到的氨基酸变化可能受到密码子使用偏差和tRNA可用性的影响.

结论:

  • 在 *Flavobacterium* 的 CII 类中发现的氨基酸变化是鱼类适应环境的潜在驱动因素.
  • 这些发现提供了对这种属的鱼类病原性演变背后的分子机制的见解.