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The evaluation stage signals the end of the nursing process. The nurse gathers evaluative data to assess whether or not the patient has attained the expected results. Whereas the nurse collects data in the nursing assessment to identify the patient's health concerns, the evaluation stage data determines if the indicated health issues are resolved. Evaluative data collection includes two sections: the data acquired to evaluate patient outcomes and the time criteria for data collection.
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评估最新的LATE-NC分期标准,使用NACCC数据进行评估.

Davis C Woodworth1,2, Katelynn M Nguyen1,2, Lorena Sordo1,2,3

  • 1Department of Neurology, University of California, Irvine, California, USA.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|October 1, 2024
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概括

2023年LATE-NC分期标准有效地捕捉了TDP-43病理的传播及其对认知的影响. 临界主导的与年龄相关的TDP-43脑病变神经病理变化 (LATE-NC) 的1b阶段显示出与认知衰退的独特关联.

关键词:
阿尔茨海默病的疾病阿尔茨海默病的疾病.国家阿尔茨海默氏症协调中心阿米格达拉的桃体痴呆症 痴呆症是一种痴呆症.衰老的海马硬化症的衰老.在海马体内,海马体边缘性主要与年龄相关的TARDNA结合蛋白43kDa脑病变神经病理变化.神经病理学神经病理学

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科学领域:

  • 神经病理学神经病理学
  • 神经科学是一个神经科学.
  • 老年学是一门学科.

背景情况:

  • 对于43kDa脑病变神经病理变化 (LATE-NC) 的边缘主导性与年龄相关的TAR DNA结合蛋白的最新分期标准于2023年发布.
  • 本研究评估了2023年LATE-NC分期标准,使用来自国家阿尔茨海默氏症协调中心的数据.

研究的目的:

  • 评估更新的LATE-NC分期标准的有效性和临床相关性.
  • 检查LATE-NC阶段,认知功能和其他神经病理变化之间的关联.

主要方法:

  • 利用多层次回归模型来分析LATE-NC阶段与认知结果之间的关联.
  • 检查了LATE-NC阶段和其他神经病理变化之间的关系,包括老化性海马硬化症 (HS-A),阿尔茨海默病NC (ADNC) 和莱维体 (LBs).

主要成果:

  • 在1352名参与者中,有37%的人表现出LATE-NC,第二阶段是最普遍的 (58%).
  • 所有LATE-NC阶段都与认知障碍有显著的关联,即使考虑到其他神经病理变化.
  • 晚期NC阶段1b,在第一阶段病例中占22%,显示出明显的关联,与认知和HS-A有关,但没有ADNC或LBs.

结论:

  • 更新后的LATE-NC分期标准有效地区分TDP-43蛋白病变的传播模式及其认知后果.
  • LATE-NC阶段1b代表了TDP-43病理的早期阶段,具有特定的关联,突出了更新的标准所捕捉到的细微差别.