活细胞介导的无催化剂自发聚合Zwitterionic甲基酸盐,用于制备益生菌载荷的水凝
Yuke Li1,2, Yiming Huang1, Zhiqiang Gao1
1Beijing National Laboratory for Molecular Sciences, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.
Angewandte Chemie (International ed. in English)
|October 1, 2024
概括
这项研究引入了一种绿色方法,用于通过细胞介导的聚合,使用内在细胞代谢,避免有害化学物质. 这一进步使得新的生物活性材料和具有定制性质的细胞疗法成为可能.
科学领域:
- 生物材料科学 生物材料科学
- 聚合物化学 聚合物化学
- 细胞工程 细胞工程
背景情况:
- 活细胞介导的聚合对生物材料来说是有希望的,但受到金属离子或激素启动器的需求的限制.
- 目前的方法限制了生物应用,需要严苛的化学条件.
研究的目的:
- 开发一种新的,绿色的方法,利用细胞内代谢活动进行细胞介导的聚合.
- 在没有外部催化剂或启动器的情况下,启动和维持zwitterionic甲基酸盐的自由基聚合.
主要方法:
- 利用活细胞的内在代谢活动来启动自由基聚合.
- 使用在细胞表面预组装的zwitterionic甲基酸盐,捕获流出的氧化还原功率.
- 在没有过渡金属催化剂,激素启动器或光源的情况下研究了聚合.
主要成果:
- 在48小时内实现了高转化 (98%) 的zwitterionic甲基酸盐,与细胞活性相关.
- 已证明的聚合过程是通过细胞的氧化还原功率和穿过膜的电子流动进行的.
- 合成了具有可调节的机械性能的水凝,并观察到细胞膜表面的变化.
结论:
- 开发了一种由细胞代谢驱动的绿色,高效的细胞介导聚合方法.
- 展示了益生菌*大肠杆菌*尼斯尔1917介导的水凝在传递治疗剂方面的潜力.
- 提升了生物活性材料合成和细胞治疗药物交付领域.
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