查的诊断准确性 对比增强乳房摄影对于乳房非常密集的女性,乳腺癌的风险增加
Noam Nissan1, Christopher E Comstock1, Varadan Sevilimedu1
1From the Department of Radiology, Memorial Sloan Kettering Cancer Center, 300 E 66th St, New York, NY 100065.
Radiology
|October 1, 2024
概括
与标准乳房影像相比,增强对比度的乳房影像 (CEM) 显著改善了与标准乳房影像相比,在乳房非常密集的女性中检测乳腺癌. 虽然CEM提供了更高的灵敏度,但其特异性较低,尽管随着后续检查而改善.
科学领域:
- 放射学 放射学是一门学科.
- 在瘤学瘤学.
- 医疗成像医学成像
背景情况:
- 乳房图解对于乳房非常密集的女性 (BI-RADS类别D) 是一个具有增加乳腺癌风险的群体具有挑战性.
- 增强对比度的乳房造影 (CEM) 是一个潜在的替代方案,但关于其在这个特定人群中的有用性的数据是有限的.
研究的目的:
- 评估CEM在乳腺癌查中对乳腺非常密集的女性的诊断性能.
主要方法:
- 对1299名乳腺密度极高的无症状女性进行CEM检查的回顾性研究 (2012年12月至2022年3月).
- 低能量的 (LE) 乳房学图像与CEM图像 (LE + 重组对比增强图像) 的诊断性能 (灵敏度,特异性) 的比较.
- 使用麦克纳马测试进行统计分析.
主要成果:
- 与单独的LE成像相比,CEM检测到11种额外的癌症 (增量率:每1000次检查中有8.7).
- CEM敏感度 (88.9%) 显著高于LE成像敏感度 (27.8%) (P = .003).
- CEM特异性 (88.9%) 低于LE成像特异性 (96.2%) (P < .001),但在随访时有所改善 (90.7%).
结论:
- 与标准乳房扫描相比,CEM在乳腺非常密集的女性中对乳腺癌检测的敏感性更高.
- CEM的特异性较低,但随着随访而改善,这表明它在这个高风险群体中的价值.
- 需要进一步评估,以优化CEM在查密集乳房中的作用.
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