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Updated: Jun 11, 2025

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脂肪肝疾病中的TGF-β/Smad信号通路:一个病例控制研究

Amir Mohammad Zargar1,2, Zahra Ali1,2, Aida Fallah3

  • 1Department of Clinical Biochemistry, Faculty of Medicine, Hamadan University of Medical Sciences, Shahid Fahmideh Street, Hamadan, Iran.

Molecular biology reports
|October 1, 2024
PubMed
概括

与代谢功能障碍相关的脂肪肝疾病 (MAFLD) 涉及白细胞 (WBC) 中改变的TGF-β信号传递. 这项研究发现,与对照人群相比,MAFLD和非MAFLD患者的TGF-β通路基因和蛋白质表达有明显的变化.

关键词:
马夫尔德 (MAFLD) 是一个在P-smad2/3/3中使用.斯马德2/3 在线观看在TGF-β1中.在TGF-β3中.其他非MAFLD.

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The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...
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