在2型糖尿病或肥胖症中,谁以及如何查内源性高皮质醇症?
Valentina Guarnotta1, Carla Giordano2, Giuseppe Reimondo3
1Section of Endocrinology, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties "G. D'Alessandro" (PROMISE), University of Palermo, Piazza delle Cliniche 2, Palermo, 90127, Italy. valentina.guarnotta@unipa.it.
在2型糖尿病 (T2DM) 或肥胖患者中,查库辛综合征 (CS) 是至关重要的. 一夜间1mg德克萨米他抑制试验 (DST) 和深夜的唾液皮质醇是有效的查工具.
科学领域:
- 内分泌学 在内分泌学.
- 代谢障碍 代谢障碍 代谢障碍
- 诊断的准确性 诊断的准确性
背景情况:
- 过高皮质醇,一种皮质醇过多的情况,与2型糖尿病 (T2DM) 和肥胖有关.
- 在这些患者群体中识别库辛综合征 (CS) 对于及时诊断和管理至关重要.
研究的目的:
- 审查T2DM或肥胖患者确诊的高皮质醇症的患病率.
- 分析选测试对库辛综合征 (CS) 的准确性.
- 引导这些风险群体中CS的查策略.
主要方法:
- 一篇关于T2DM或肥胖症中高皮质醇症患病率的出版物的叙述性综述.
- 分析用于CS检测的选试验.
主要成果:
- 在T2DM中CS的患病率从0.6%到9.3%不等.
- 通常使用的是1毫克夜间德克萨米他抑制试验 (DST),错误阳性率为3.7-21%.
- 肥胖中CS的患病率通常在1%左右,其中1mg DST和深夜唾液皮质醇 (LNSC) 是准确的查测试.
结论:
- 临床专业知识和CS污名的评估是识别需要查的患者的关键.
- 在T2DM患者中,夜间1mg DST似乎是最准确的CS查.
- 对于肥胖患者,LNSC和夜间1mg DST都适合用于高皮质醇症查.
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