右心室纵向应变与高血压患者的不良结果之间的关系:10年随访
Marijana Tadic1, Jelena Suzic2, Aleksandra Sljivic2
1Department of Cardiology, University Clinical Hospital Center "Dr. Dragisa Misovic - Dedinje", Belgrade, 11000, Serbia. marijana_tadic@hotmail.com.
概括
减少右心室 (RV) 纵向应变,这是一种心脏功能的敏感指标,与高血压患者的不良结果有关. 这一发现突显了RV菌株的突出.
科学领域:
- 心脏病学 心脏病学
- 心声回声扫描 (Echocardiography) 是一种心声回声扫描.
- 高血压研究 高血压研究
背景情况:
- 右心室 (RV) 改造在动脉高血压中至关重要.
- RV纵向菌株是早期心脏功能障碍的敏感标志物.
- 在高血压中RV纵向菌株的临床意义仍未确立.
研究的目的:
- 调查RV纵向菌株 (全球和自由壁) 与主要不良心血管事件 (MACE) 之间的关联.
- 评估RV菌株对大量高血压患者长期不良结果的预测价值.
- 确定RV纵向菌株在治疗动脉高血压方面的临床重要性.
主要方法:
- 544名高血压患者的回顾性分析,具有完整的心声回声图数据.
- 使用2D斑点跟踪成像来评估RV全球和自由墙纵向应变.
- 定义MACE作为一个复合终点,包括死亡率,心肌梗塞,中风,心力衰竭和心房动在10年的随访期间.
主要成果:
- 经历MACE的患者年龄较大;在人口统计学或临床参数方面没有发现显著差异.
- 虽然RV直径相似,但MACE患者的RV壁厚度增加.
- 在MACE患者中观察到显著较低的VR全球纵向应变 (-22.3 ± 3.6%对 -24.7 ± 3.9%) 和自由壁纵向应变 (-25.8 ± 4.2%对 -28.1 ± 4.5%) (p < 0.001).
- 减少的RV GLS和自由壁纵向菌株是MACE的独立预测因素 (分别为OR 1.10和1.21).
结论:
- 全球RV纵向菌株和RV自由壁纵向菌株独立地与不良结果相关.
- 这些发现表明,RV菌株参数是高血压患者有价值的预后标志物.
- 这项研究强调了在长期高血压管理中通过应变分析评估RV功能的重要性.
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