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Updated: Jul 23, 2026

In Vivo Modeling of the Morbid Human Genome using Danio rerio
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使用单细胞贝叶斯双聚类框架分析疾病进展期间功能基因模块扰动的协议

Kunyue Wang1, Yuqiao Gong1, Zixin Yan1

  • 1Department of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 800 Dongchuan Road, Minhang District, Shanghai 200240, China.

STAR protocols
|October 1, 2024
PubMed
概括

这项研究引入了一种单细胞贝叶斯双聚类 (scBC) 方法,用于分析复杂疾病中的功能基因模块扰动. 该协议有助于了解疾病进展期间跨细胞类型的基因调节.

关键词:
生物信息学是一种生物信息学.遗传学 是一个遗传学.神经科学是一个神经科学.

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相关概念视频

Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...