18岁时认知功能的差异解释了低教育和早期痴呆风险之间的关联
Bernt Bratsberg1,2, Anders M Fjell3,4, Ole J Rogeberg1
1Ragnar Frisch Centre for Economic Research, Oslo 0349, Norway.
概括
年轻人的认知功能低下显著增加了痴呆症的风险,独立于家庭因素. 虽然低教育水平表明与痴呆症有联系,但它与痴呆症有关.
科学领域:
- 神经科学是一个神经科学.
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 痴呆症预防策略通常针对可修改的风险因素,如教育.
- 教育,认知和痴呆症之间的关系是复杂的,因为混因素.
- 需要大量的人口研究来解开这些关联.
研究的目的:
- 调查教育和认知功能与痴呆风险的独立关联.
- 确定家庭因素对教育与痴呆症关系的影响.
主要方法:
- 研究了一组207,814名出生于1950-1959年的挪威男性.
- 在征兵期间的认知测试评估了早期的认知功能.
- 60-69岁之间的痴呆症诊断被分析使用生存分析,控制教育和其他因素.
主要成果:
- 低认知分数与痴呆症风险翻倍相关 (HR=2.00),独立于教育和家庭因素.
- 低教育程度与痴呆风险之间的关联在很大程度上是由家庭因素解释的.
- 早期的认知功能似乎比教育水平更强烈地预测痴呆症.
结论:
- 提高儿童和青少年的认知功能可能是一个比仅仅专注于教育更有效的痴呆症预防策略.
- 认知能力,而不是教育程度,是痴呆症的关键独立风险因素.
- 非家族因素在认知功能与痴呆症的联系中起着更重要的作用.
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