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Updated: Jun 11, 2025

Ex Vivo Oculomotor Slice Culture from Embryonic GFP-Expressing Mice for Time-Lapse Imaging of Oculomotor Nerve Outgrowth
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一种导致镜像运动障碍的人类DCC变异揭示了WAVE调节复合体通过网-1-DCC调节轴突指导

Karina Chaudhari1, Kaiyue Zhang2,3, Patricia T Yam2

  • 1Department of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

Science signaling
|October 1, 2024
PubMed
概括

先天性镜像运动 (CMM) 可能源于改变的网林-1信号传递. 一种DCC受体变体破坏了与WAVE调节复合体 (WRC) 的相互作用,损害了轴突引导,并可能导致CMM.

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