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Lisa U Teufel¹, Esther J M Taks¹, Jelle van Gemert¹

¹Department of Internal Medicine, Radboudumc Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands.

|October 1, 2024

概括

介素-38 (IL-38) 可能通过降低免疫细胞中的抗原呈现和细胞化来降低疫苗的有效性. 较低的抗体反应与疫苗接种后较高的IL-38水平有关.

科学领域:

免疫学免疫学免疫学
疫苗学疫苗学疫苗学
分子生物学分子生物学

背景情况:

低的疫苗反应限制了对感染的保护.
介质蛋白-38 (IL-38),IL-1家族成员,调节炎症,最近被证明可以抑制抗体的产生.
通过IL-38影响免疫反应的确切机制,特别是抗原呈现,仍然不清楚.

研究的目的:

研究IL-38对抗原呈现细胞 (APC) 的作用及其与疫苗免疫性相关性.
确定IL-38如何影响细胞因子的产生,细胞和关键分子 (MHC II,共刺激蛋白) 在人体外周血液单核细胞 (PBMC) 和骨髓系衍生树突细胞 (MDDC) 上的表达.
为了将血IL-38水平与BCG和Tdap-IPV接种疫苗的个体中的抗体反应相关联.

主要方法:

在人体PBMCs和MDDCs上使用复合人体IL-38进行体外实验,以评估细胞因子的产生,细胞化和表面标记物表达 (MHC II,CD83,CD40,CD86).
在BCG和Tdap-IPV疫苗接种后的75名女性 (年龄在18-48岁) 队列中分析血IL-38度.
在接种疫苗后8个月内,血IL-38度与对喉毒素的抗体产生之间的相关性分析.

主要成果:

IL-38显著降低了PBMCs上的HLA-DR,HLA-DM和CD83的表达.
在MDDC上,IL-38降低了协同刺激分子CD40和CD86的表达.
单细胞化能力受到IL-38的损害,较高的IL-38度与抗白喉毒素的抗体产生有负相关性.

结论:

通过降低抗原呈现和细胞化,IL-38可能会降低疫苗的有效性.
这些发现表明IL-38在调节某些疫苗类型免疫性方面的作用.
向IL-38可能会增强疫苗的反应,并改善对感染的保护.

关键词:

抗体是一种抗体.介质蛋白-38 介质蛋白-38 介质蛋白-38 没有响应的非响应者.疫苗接种疫苗接种

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