在计算机断层扫描上,较高的小肺动脉和静脉体积与目前和前吸烟者的死亡率有关
Anastasia K A L Kwee1, Eleni-Rosalina Andrinopoulou2, Tjeerd van der Veer3
1University Medical Centre Utrecht and Utrecht University, Dept. Radiology, Utrecht, Netherlands.
EBioMedicine
|October 1, 2024
概括
吸烟者的异常高的小动脉和静脉体积与死亡率的增加有关. 需要进一步的研究来了解这些小肺血管变化的原因及其对心脏功能的影响.
科学领域:
- 肺部医学 肺部医学
- 心血管研究研究心血管研究
- 放射学 放射学是一门学科.
背景情况:
- 慢性阻塞性肺病 (COPD) 的血管变化与缺氧和肺高血压有关.
- 小血管异常对COPD患者死亡率的具体影响仍在调查中.
研究的目的:
- 用计算机断层扫描 (CT) 来量化吸烟者的小动脉和静脉体积.
- 确定小动脉和静脉体积与大量吸烟者的所有原因死亡率的独立关联.
- 对于具有较高的小动脉或静脉体积的个体来说.
主要方法:
- 计算机断层扫描 (CT) 用于测量动脉和静脉尺寸到0.2毫米.
- 小血管体积 (直径<1毫米) 根据身体表面积正常化.
- 多变量考克斯模型分析了7903名COPDGene研究参与者的小血管体积和死亡率之间的关联.
主要成果:
- 高小动脉和高小静脉体积独立地与死亡率增加有关.
- 小动脉体积的增加与1.07的危险比率相关,而小静脉体积的危险比率为1.34每毫升/平方米.
- 具有较高小动脉或静脉体积的受试者表现出更多的肺气,空气陷和严重的冠状动脉化.
结论:
- 异常高的小肺动脉和静脉体积是吸烟者死亡率的重要预测因素.
- 这些发现强调了进一步研究小肺血管异常的病因及其对吸烟者的心脏功能影响的必要性.
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