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对于药物输送和向治疗系统的刺激响应黄金纳米棒的进展
Sakineh Hajebi1, Mohsen Chamanara1, Shadi Sadat Nasiri2
1Toxicology Research Center, AJA University of Medical Sciences, Tehran, Iran; Biomaterial and Medicinal Chemistry Research Center, AJA University of Medical Science, Tehran, Iran.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
|October 1, 2024
概括
黄金纳米棒 (AuNRs) 为有针对性的治疗,成像和药物输送提供可调节的特性. 响应刺激的AuNR增强治疗效果和控制药物释放,显示出临床翻译的希望.
科学领域:
- 生物医学工程 生物医学工程
- 材料科学 材料科学 材料科学
- 纳米技术 纳米技术
背景情况:
- 黄金纳米棒 (AuNRs) 具有独特的光学和物理化学特性,对生物医学应用有价值.
- 它们的生物相容性和可调节的等离子体特性使它们适用于向治疗,成像和药物输送.
- 刺激响应系统对于在特定地点控制货物释放至关重要.
研究的目的:
- 审查刺激响应黄金纳米棒 (AuNRs) 的生物医学应用.
- 总结AuNRs的内源和外源刺激反应性质,双重/多功能性和临床交付潜力.
- 突出AuNR设计策略,优势,挑战和生物集成纳米组件的临床转化.
主要方法:
- 在生物医学应用中对刺激响应的金纳米棒进行文献综述.
- 分析AuNR的特性,包括光学,物理化学和生物相容性.
- 讨论内源性和外源性刺激,双重/多重刺激反应,以及临床翻译.
主要成果:
- AuNRs是针对性治疗,成像和药物输送的有效工具,由各种刺激触发.
- 响应双/多刺激的AuNR为治疗应用提供了增强的控制和特异性.
- 最近的设计策略提高了使用AuNRs的治疗疗效和药物释放控制.
结论:
- 对刺激有反应的AuNRs代表了高级疾病治疗和药物输送的有希望的平台.
- 对AuNR设计和临床转化进行进一步的研究对于实现其全部治疗潜力至关重要.
- 解决临床翻译方面的挑战是成功实施基于AuNR的治疗方法的关键.
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