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在晚期细胞癌患者中,LINC00365作为全切除的潜在生物标志物

Fatemeh Taghavinia¹, Iman Akhlaghipour², Alireza Golshan³

¹Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Pathology, research and practice

|October 1, 2024

概括

长非编码RNA LINC00365在晚期细胞癌 (RCC) 和老年患者中被上调. 这一发现表明,LINC00365可以作为高风险个体的诊断标记.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
遗传学是一个遗传学.

背景情况:

细胞癌 (RCC) 是一种常见的尿道癌,在转移阶段的预后不佳.
了解RCC进展需要识别新的诊断和治疗标志物.
长非编码RNA (lncRNAs) 在RCC发育过程中在调节分子机制方面发挥着至关重要的作用.

研究的目的:

评估LINC00365在细胞癌 (RCC) 患者的表达水平.
研究LINC00365作为RCC的诊断瘤标志物的潜力.

主要方法:

收集了50个新鲜的RCC瘤组织和相邻的正常边缘.
量化的LINC00365表达水平.
与临床病理学特征相关的LINC00365表达.

主要成果:

与男性相比,女性患者的LINC00365表达显著上调 (p=0.050).
晚期RCC瘤的上调显著高于初级阶段瘤 (p=0.035).
经过全切除的60岁以上患者与年轻患者相比,表现出显著的LINC00365上调 (p=0.039).

结论:

晚期RCC和老年患者中LINC00365表达的升高表明其作为高风险个体的诊断标记的实用性.
女性患者LINC00365的增加表明潜在的性别特异性诊断标记.
需要进一步评估LINC00365在血清中的研究来确认其临床可靠性.

关键词:

诊断诊断诊断诊断是一个我们的 LINC0036565 联系方式细胞癌是脏细胞的癌症.这是一种瘤标志物.

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相关概念视频

lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...