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模仿和分析瘤的微环境

Roxane Crouigneau¹, Yan-Fang Li², Jamie Auxillos³

¹Section for Cell Biology and Physiology, Department of Biology, University of Copenhagen, Copenhagen, Denmark.

Cell reports methods

|October 1, 2024

概括

瘤微环境 (TME) 显著影响癌症进展和治疗结果. 了解TME复杂性需要先进的模型和高分辨率的分析工具,以有效进行癌症研究.

科学领域:

在瘤学瘤学.
癌症生物学癌症生物学
生物医学工程生物医学工程

背景情况:

瘤微环境 (TME) 对固体瘤的发展和治疗反应至关重要.
像缺氧,酸性和异质性这样的TME特征影响癌症的攻击性和抵抗力.
癌细胞及其环境之间的复杂相互作用推动了疾病的进展.

研究的目的:

审查TME研究当前模型和方法的优点和局限性.
为了指导未来的研究方向,了解TME.
概述分析复杂的TME的挑战.

主要方法:

审查关于TME模型和分析工具的现有文献.
评估复杂的癌症模型用于TME属性控制和分析.
对TME复杂性的高分辨率分析技术的评估.

主要成果:

在癌症发展和治疗耐药性方面,TME的作用是多方面的.
复杂的模型和高分辨率工具对于TME研究至关重要.
当前的模型和方法具有特定的优势和局限性.

结论:

需要进一步的研究才能充分理解TME.
开发先进的模型和分析技术至关重要.
解决TME复杂性是改善癌症治疗的关键.

关键词:

CP: 生物技术生物技术 CP:癌症生物学癌症生物学癌症癌症癌症癌症癌症异质性的异质性代谢过程中的代谢.微流体学在微流体学方面有机生物有机物瘤微环境是一个微环境.瘤模型瘤模型

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The Tumor Microenvironment

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...