跨性别男性的子宫内膜癌和子宫内膜变化:日本人对丸激素的见解
Mariko Nakahara1, Hiroshi Yoshida2, Aiko Sakamoto3
1Department of Gynecology, National Cancer Center Hospital, Tokyo, Japan.
The journal of obstetrics and gynaecology research
|October 1, 2024
概括
子宫内膜癌可能与严重肥胖和跨性别男性长期使用丸激素有关. 需要进一步的研究来证实这些发现,并建立针对日本跨性别男性的查指南.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 在瘤学瘤学.
- 跨性别者健康 跨性别者健康
背景情况:
- 使用丸激素的跨性别男性 (TGM) 的子宫内膜变化尚未得到充分理解.
- 关于这一群体内子宫内膜癌发病率的数据有限.
研究的目的:
- 报告日本TGM治疗丸激素的子宫内膜癌症病例.
- 从现有文献中审查类似的案例.
- 调查子宫内膜癌,严重肥胖和在TGM中使用的相关性.
主要方法:
- 对2名患有子宫内膜癌的TGM和43名没有癌症的TGM进行了性别确认手术的临床数据的回顾性分析.
- 对TGM与子宫内膜癌的文献综述.
- 女性生殖器官的组织病理学评估.
主要成果:
- 两个患有子宫内膜癌的TGM和四个文献病例共享严重肥胖 (BMI ≥30 kg/m2) 和长期使用丸激素.
- 在没有癌症的TGM中,30%患有肥胖 (BMI≥25 kg/m2),77%患有多囊性卵巢变化.
- 在没有癌症的TGM中,在丸激素使用时间和BMI之间发现了显著的相关性.
结论:
- 严重的肥胖,长期使用丸激素和子宫内膜癌可能与TGM有关.
- 焦点增殖性子宫内膜在丸激素治疗的TGM中很常见.
- 需要进行更大规模的研究来证实这些发现,并制定针对日本TGM的查方案.
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