轨道前皮层介导持续的底侧杏仁体编码 Cued 寻求奖励的状态
David J Ottenheimer1,2,3, Katherine R Vitale4, Frederic Ambroggi5
1Department of Psychological and Brain Sciences, Krieger School of Arts and Sciences, Johns Hopkins University, Baltimore, Maryland 21218.
概括
底侧杏仁体 (BLA) 通过持续的神经活动编码寻求奖励的行为. 这种神经代码受到轨道前皮层 (OFC) 的影响,对于保持有动机的行为至关重要.
科学领域:
- 神经科学是一个神经科学.
- 行为神经科学 行为神经科学
- 系统神经科学 系统神经科学
背景情况:
- 底侧杏仁体 (BLA) 参与处理情绪突出刺激.
- 了解BLA动态在寻求奖励的行为,特别是在不确定性下,是一个活跃的研究领域.
研究的目的:
- 调查BLA神经活动如何与有条件的奖励寻求的获取和灭绝有关.
- 探索轨道前皮层 (OFC) 在寻求奖励期间调节BLA活动中的作用.
主要方法:
- 在有条件的寻求奖励任务期间,在雄性大鼠中记录了单个BLA神经元活动.
- 使用了OFC无活化和BLA和OFC终端的光遗传学操纵.
- 评估神经动力学对有条件刺激 (CS+) 和无条件奖励的反应.
主要成果:
- BLA神经元表现出持续的提示唤起活动,与行为相关,并在奖励后终止.
- 大多数BLA神经元在诱导寻求奖励的过程中表现出长时间的抑制.
- 经过OFC无活化,持续的BLA活动会减弱,并减少寻求奖励的行为.
- BLA和OFC通路的光遗传学破坏损害了寻求奖励的行为.
结论:
- BLA通过持续的,双向的提示驱动的神经编码来代表寻求奖励的状态.
- 皮层输入,特别是来自OFC,调节了这个BLA代码.
- 这种神经表现对于保持警寻求奖励的行为至关重要.
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