基于深度学习的疾病分类在接受电影心脏MRI的患者中
Athira J Jacob1, Teodora Chitiboi1, U Joseph Schoepf2
1Digital Technology and Innovation, Siemens Healthineers, Princeton, New Jersey, USA.
Journal of magnetic resonance imaging : JMRI
|October 1, 2024
概括
这项研究开发了一个使用MRI数据来分类心血管疾病的深度学习算法. 该算法在区分正常受试者与患有扩张性心肌病,多变性心肌病和缺血性心脏病的患者方面取得了高准确性.
科学领域:
- 心血管成像 - 心血管成像
- 人工智能在医学中的应用
- 医学图像分析 医学图像分析
背景情况:
- 通过MRI对心血管疾病的自动分析可以提供快速和可重复的临床评估.
- 深度学习 (DL) 提供了从医学成像中自动化疾病分类的潜力.
研究的目的:
- 开发一种DL算法,使用MRI数据对心血管疾病进行分类.
- 该算法旨在区分正常受试者 (NORM) 和患有扩张性心肌病 (DCM),多变性心肌病 (HCM) 和缺血性心脏病 (IHD) 的患者.
主要方法:
- 这是一项追溯性研究,涉及1337名受试者 (568名NORM,151名DCM,177名HCM,441名IHD).
- 双心室形态,功能和左心室应变特征自动从电影MRI中提取.
- 变量自编码器模型被训练并使用十倍交叉验证进行评估.
主要成果:
- DL算法实现了高的曲线下面面积 (AUC) 值:0.952 (NORM),0.881 (DCM),0.908 (HCM) 和0.856 (IHD),整体精度为0.778.
- 正常类的特异性为0.908,在使用未标记数据的联合训练中增加到0.961.
- 菌株特征被确定为疾病分类的重要特征.
结论:
- 从电影MRI中自动提取的心脏功能特征显示出疾病分类的前景,特别是正常-异常差异化.
- 菌株特征在准确的疾病标记中起着重要作用.
- 与未标记数据的共同训练可以增强正常-异常分类的特异性.
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